Front Cover: A Synbiotic Ameliorates Con A-Induced Autoimmune Hepatitis in Mice through Modulation of Gut Microbiota and Immune Imbalance

Mol. Nutr. Food Res. 2023, 67, 202200428

DOI: 10.1002/mnfr.202200428

The intestinal flora of AIH mice is disordered, the intestinal barrier is destroyed, LPS migrates to liver and activates the TLR4/NF-κB inflammatory pathway leading to liver injury. Gavage of Pro, Pre and Syn reverse this state. Postbiotics inhibit LPS-induced activation of TLR4/NF-κB pathway and reduce inflammatory factors in vitro. This is reported by Weiping Fan and co-workers in article number 2200428.