A Natural Eumelanin-Assisted Pullulan/Chitosan Hydrogel for the Management of Diabetic Oral Ulcers
Ying Li
School of Chemical Engineering, Nanjing University of Science & Technology, Nanjing, Jiangsu, 210094 China
Search for more papers by this authorYajing Xiang
School & Hospital of Stomatology, Wenzhou Medical University, Wenzhou, Zhejiang, 325027 China
Search for more papers by this authorYuxi Chen
School & Hospital of Stomatology, Wenzhou Medical University, Wenzhou, Zhejiang, 325027 China
Search for more papers by this authorYingying Wang
Department of Otolaryngology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, 325000 China
Search for more papers by this authorWei Dong
School of Chemical Engineering, Nanjing University of Science & Technology, Nanjing, Jiangsu, 210094 China
Search for more papers by this authorCorresponding Author
Yan Liu
School of Chemical Engineering, Nanjing University of Science & Technology, Nanjing, Jiangsu, 210094 China
E-mail: [email protected]; [email protected]; [email protected]
Search for more papers by this authorCorresponding Author
Xiaoliang Qi
National Engineering Research Center of Ophthalmology and Optometry, Eye Hospital, Wenzhou Medical University, Wenzhou, Zhejiang, 325027 China
E-mail: [email protected]; [email protected]; [email protected]
Search for more papers by this authorCorresponding Author
Jianliang Shen
National Engineering Research Center of Ophthalmology and Optometry, Eye Hospital, Wenzhou Medical University, Wenzhou, Zhejiang, 325027 China
Zhejiang Engineering Research Center for Tissue Repair Materials, Wenzhou Institute, University of Chinese Academy of Sciences, Wenzhou, Zhejiang, 325001 China
E-mail: [email protected]; [email protected]; [email protected]
Search for more papers by this authorYing Li
School of Chemical Engineering, Nanjing University of Science & Technology, Nanjing, Jiangsu, 210094 China
Search for more papers by this authorYajing Xiang
School & Hospital of Stomatology, Wenzhou Medical University, Wenzhou, Zhejiang, 325027 China
Search for more papers by this authorYuxi Chen
School & Hospital of Stomatology, Wenzhou Medical University, Wenzhou, Zhejiang, 325027 China
Search for more papers by this authorYingying Wang
Department of Otolaryngology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, 325000 China
Search for more papers by this authorWei Dong
School of Chemical Engineering, Nanjing University of Science & Technology, Nanjing, Jiangsu, 210094 China
Search for more papers by this authorCorresponding Author
Yan Liu
School of Chemical Engineering, Nanjing University of Science & Technology, Nanjing, Jiangsu, 210094 China
E-mail: [email protected]; [email protected]; [email protected]
Search for more papers by this authorCorresponding Author
Xiaoliang Qi
National Engineering Research Center of Ophthalmology and Optometry, Eye Hospital, Wenzhou Medical University, Wenzhou, Zhejiang, 325027 China
E-mail: [email protected]; [email protected]; [email protected]
Search for more papers by this authorCorresponding Author
Jianliang Shen
National Engineering Research Center of Ophthalmology and Optometry, Eye Hospital, Wenzhou Medical University, Wenzhou, Zhejiang, 325027 China
Zhejiang Engineering Research Center for Tissue Repair Materials, Wenzhou Institute, University of Chinese Academy of Sciences, Wenzhou, Zhejiang, 325001 China
E-mail: [email protected]; [email protected]; [email protected]
Search for more papers by this authorAbstract
Existing methods for treating diabetic oral ulcers often fall short in clinical environments due to potential bacterial contamination, oxidative harm, and hindered angiogenesis throughout the healing process. Here, a hydrogel patch (HYG2) have been developed for local in situ application. HYG2 comprises oxidized pullulan, quaternized chitosan, and eumelanin nanoparticles derived from cuttlefish ink. These components work together to efficiently heal wounds associated with diabetic oral ulcers. Application begins with a simple local injection that quickly forms a protective barrier over the mucosa, effectively stopping bleeding and counteracting inflammatory agents. HYG2 is distinguished by its strong antibacterial properties and capacity to eliminate reactive oxygen species, promoting bacteria clearance and managing oxidative stress, which accelerates the healing phase from inflammation to tissue regeneration. Additionally, HYG2's 3D structure, incorporating elements from natural sources, offers exemplary support for structural and nutritional cell needs. This enhancement fosters cell adhesion, migration, and proliferation, along with further angiogenesis during mucosal remodeling. Ultimately, HYG2 is fully absorbed by the body after serving its therapeutic functions. Evidence from in vitro and in vivo studies shows that HYG2 hydrogel markedly accelerates mucosal wound repair, making it a promising treatment for diabetic oral ulcers.
Conflict of Interest
The authors declare no conflict of interest.
Open Research
Data Availability Statement
The data that support the findings of this study are available from the corresponding author upon reasonable request.
Supporting Information
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