Gelatin-Alginate Gels and Their Enzymatic Modifications: Controlling the Delivery of Small Molecules
Marie-Cécile Klak
ERRMECe Lab., Université de Cergy-Pontoise, i-MAT, PRES UPGO, BP222–95000 Cergy Pontoise, France
Maia Woundcare 1, mail Gay Lussac 95000 CergyPontoise, France
Search for more papers by this authorElodie Lefebvre
ERRMECe Lab., Université de Cergy-Pontoise, i-MAT, PRES UPGO, BP222–95000 Cergy Pontoise, France
Search for more papers by this authorLaure Rémy
ERRMECe Lab., Université de Cergy-Pontoise, i-MAT, PRES UPGO, BP222–95000 Cergy Pontoise, France
Search for more papers by this authorRémy Agniel
ERRMECe Lab., Université de Cergy-Pontoise, i-MAT, PRES UPGO, BP222–95000 Cergy Pontoise, France
Search for more papers by this authorJulien Picard
Maia Woundcare 1, mail Gay Lussac 95000 CergyPontoise, France
Search for more papers by this authorSébastien Giraudier
Maia Woundcare 1, mail Gay Lussac 95000 CergyPontoise, France
Search for more papers by this authorCorresponding Author
Véronique Larreta-Garde
ERRMECe Lab., Université de Cergy-Pontoise, i-MAT, PRES UPGO, BP222–95000 Cergy Pontoise, France
ERRMECe Lab., Université de Cergy-Pontoise, i-MAT, PRES UPGO, BP222–95000 Cergy Pontoise, FranceSearch for more papers by this authorMarie-Cécile Klak
ERRMECe Lab., Université de Cergy-Pontoise, i-MAT, PRES UPGO, BP222–95000 Cergy Pontoise, France
Maia Woundcare 1, mail Gay Lussac 95000 CergyPontoise, France
Search for more papers by this authorElodie Lefebvre
ERRMECe Lab., Université de Cergy-Pontoise, i-MAT, PRES UPGO, BP222–95000 Cergy Pontoise, France
Search for more papers by this authorLaure Rémy
ERRMECe Lab., Université de Cergy-Pontoise, i-MAT, PRES UPGO, BP222–95000 Cergy Pontoise, France
Search for more papers by this authorRémy Agniel
ERRMECe Lab., Université de Cergy-Pontoise, i-MAT, PRES UPGO, BP222–95000 Cergy Pontoise, France
Search for more papers by this authorJulien Picard
Maia Woundcare 1, mail Gay Lussac 95000 CergyPontoise, France
Search for more papers by this authorSébastien Giraudier
Maia Woundcare 1, mail Gay Lussac 95000 CergyPontoise, France
Search for more papers by this authorCorresponding Author
Véronique Larreta-Garde
ERRMECe Lab., Université de Cergy-Pontoise, i-MAT, PRES UPGO, BP222–95000 Cergy Pontoise, France
ERRMECe Lab., Université de Cergy-Pontoise, i-MAT, PRES UPGO, BP222–95000 Cergy Pontoise, FranceSearch for more papers by this authorAbstract
The release of molecules entrapped within biogels is dictated by diffusion laws. Innovative biogel architectures are conceived and tested to control small molecule delivery from gelatin gels. The ionic interactions modulate the release of small molecules. Alginate is then added to gelatin gels and further hydrolyzed; the influence of viscosity is discussed. Next, various mixed gels are compared, such as a gelatin-alginate IPN and the original architecture of an alginate gel entrapped in a gelatin gel with or without a polysaccharidase. The relative influence of ionic interactions and diffusional constraints on the delivery of small charged molecules is explored, and a solution for controlling diffusion is proposed for any situation.
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