Volume 55, Issue 10 pp. 2315-2324

Article

Studies on the Chemical Reactions of Some 3-Substituted-6,8-dimethylchromones with Nucleophilic Reagents

Magdy A. Ibrahim,

Corresponding Author

Magdy A. Ibrahim

[email protected]

orcid.org/0000-0001-5639-9522

Department of Chemistry, Faculty of Education, Ain Shams University, Roxy, Cairo, 11711 Egypt

E-mail: [email protected]Search for more papers by this author

Al-Shimaa Badran,

Al-Shimaa Badran

Department of Chemistry, Faculty of Education, Ain Shams University, Roxy, Cairo, 11711 Egypt

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Nasser M. El-Gohary,

Nasser M. El-Gohary

Department of Chemistry, Faculty of Education, Ain Shams University, Roxy, Cairo, 11711 Egypt

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Salsabeel H. Hashiem,

Salsabeel H. Hashiem

Department of Chemistry, Faculty of Education, Ain Shams University, Roxy, Cairo, 11711 Egypt

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Magdy A. Ibrahim,

Corresponding Author

Magdy A. Ibrahim

[email protected]

orcid.org/0000-0001-5639-9522

Department of Chemistry, Faculty of Education, Ain Shams University, Roxy, Cairo, 11711 Egypt

E-mail: [email protected]Search for more papers by this author

Al-Shimaa Badran,

Al-Shimaa Badran

Department of Chemistry, Faculty of Education, Ain Shams University, Roxy, Cairo, 11711 Egypt

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Nasser M. El-Gohary,

Nasser M. El-Gohary

Department of Chemistry, Faculty of Education, Ain Shams University, Roxy, Cairo, 11711 Egypt

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Salsabeel H. Hashiem,

Salsabeel H. Hashiem

Department of Chemistry, Faculty of Education, Ain Shams University, Roxy, Cairo, 11711 Egypt

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First published: 22 August 2018

https://doi.org/10.1002/jhet.3291

Citations: 14

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Abstract

A variety of 3-substituted-6,8-dimethylchromones have been synthesized and characterized. The chemical reactivity of 3-substituted-6,8-dimethylchromones was studied towards some nucleophiles, namely, S-benzyldithiocarbazate, o-phenylenediamine, and cyanoacetamide, and a diversity of products were efficiently synthesized. Reactions of 3-substituted-6,8-dimethylchromones (except 3-formyl-6,8-dimethylchromone), with nucleophilic reagents, usually proceed through nucleophilic attack at C-2 position followed by different types of heterocyclization depending on the functional group present at C-3 position. Structures of the newly synthesized products have been established based on elemental analysis and spectral data.

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Volume55, Issue10

October 2018

Pages 2315-2324

Studies on the Chemical Reactions of Some 3-Substituted-6,8-dimethylchromones with Nucleophilic Reagents

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Studies on the Chemical Reactions of Some 3-Substituted-6,8-dimethylchromones with Nucleophilic Reagents

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