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Facile Synthesis of 3(2H)-Pyridazinones and 2(3H)-Furanones of Anticipated Biological Activities
J. M. Morsy,
J. M. Morsy
Chemistry Department, Faculty of Education, Ain Shams University, Roxy, Cairo, Egypt
Search for more papers by this authorJ. M. Morsy,
J. M. Morsy
Chemistry Department, Faculty of Education, Ain Shams University, Roxy, Cairo, Egypt
Search for more papers by this authorAbstract
3-Aroyl-2-arylpropionic acids 2a-e were utilized to synthesize 3(2H)-pyridazinones 3a-e and 2(3H)-furanones 6 through reaction with hydrazine hydrate and freshly distilled acetic anhydride, respectively, in the hope of obtaining new 3(2H)-pyridazinones with no ulcerogenic side effect or with negligible general side effects as those currently used NSAIDS as well as biologically active 2(3H)-furanones.
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