RESEARCH ARTICLE
Induction of Endoplasmic Reticulum Stress and Aryl Hydrocarbon Receptor Pathway Expression by Blue LED Irradiation in Oral Squamous Cell Carcinoma
Hui Jiang,
Jiali Yang,
Qiqi Fu,
Angze Li,
Haokuan Qin,
Muqing Liu,
Hui Jiang
Academy for Engineering and Technology, Fudan University, Shanghai, China
Search for more papers by this authorJiali Yang
School of Information Science and Technology, Fudan University, Shanghai, China
Search for more papers by this authorQiqi Fu
School of Information Science and Technology, Fudan University, Shanghai, China
Search for more papers by this authorAngze Li
School of Information Science and Technology, Fudan University, Shanghai, China
Search for more papers by this authorHaokuan Qin
Academy for Engineering and Technology, Fudan University, Shanghai, China
Search for more papers by this authorCorresponding Author
Muqing Liu
School of Information Science and Technology, Fudan University, Shanghai, China
Zhongshan DB-Light Technology Co., Ltd, Zhongshan City, Guangdong Province, China
Correspondence:
Muqing Liu ([email protected])
Search for more papers by this authorHui Jiang,
Jiali Yang,
Qiqi Fu,
Angze Li,
Haokuan Qin,
Muqing Liu,
Hui Jiang
Academy for Engineering and Technology, Fudan University, Shanghai, China
Search for more papers by this authorJiali Yang
School of Information Science and Technology, Fudan University, Shanghai, China
Search for more papers by this authorQiqi Fu
School of Information Science and Technology, Fudan University, Shanghai, China
Search for more papers by this authorAngze Li
School of Information Science and Technology, Fudan University, Shanghai, China
Search for more papers by this authorHaokuan Qin
Academy for Engineering and Technology, Fudan University, Shanghai, China
Search for more papers by this authorCorresponding Author
Muqing Liu
School of Information Science and Technology, Fudan University, Shanghai, China
Zhongshan DB-Light Technology Co., Ltd, Zhongshan City, Guangdong Province, China
Correspondence:
Muqing Liu ([email protected])
Search for more papers by this authorFunding: This work was supported by Zhongshan Science and Technology Bureau under grant No. 2021AG001.
ABSTRACT
Photobiomodulation therapy, as an emerging treatment modality, has been widely used in dentistry. However, reports on blue light therapy for oral cancer are scarce. This study investigated the effects of 457 and 475 nm LED irradiation on SCC-25 cells and explored the potential mechanisms underlying the impact of blue light. Both wavelengths were found to inhibit cell viability, induce oxidative stress, and cause cell cycle arrest without leading to cell death. Notably, the inhibitory effect of 457 nm blue light on cell proliferation was more sustained. Transcriptome sequencing was performed to explore the underlying mechanisms, revealing that blue light induced endoplasmic reticulum stress in SCC-25 cells, with 457 nm light showing a more pronounced effect. Moreover, 457 nm blue light upregulated the expression of the aryl hydrocarbon receptor pathway, indicating potential therapeutic prospects for the combined use of blue light and pharmacological agents.
Conflicts of Interest
The authors declare no conflicts of interest.
Open Research
Data Availability Statement
The data that support the findings of this study are available from the corresponding author upon reasonable request.
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