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Treatment of tumor in lymph nodes using near-infrared laser light-activated thermosensitive liposome-encapsulated doxorubicin and gold nanorods

Daisuke Matsuki

Laboratory of Biomedical Engineering for Cancer, Department of Biomedical Engineering, Graduate School of Biomedical Engineering, Tohoku University, 4-1 Seiryo, Aoba, Sendai, 980-8575 Japan

Biomedical Engineering Cancer Research Center, Graduate School of Biomedical Engineering, Tohoku University, 4-1 Seiryo, Aoba, Sendai, 980-8575 Japan

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Oladipo Adewale,

Oladipo Adewale

Department of Applied Chemistry, University of Johannesburg, Doornfontein Campus P.O. Box 17011, Doornfontein, 2028 South Africa

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Sachiko Horie,

Sachiko Horie

Laboratory of Biomedical Engineering for Cancer, Department of Biomedical Engineering, Graduate School of Biomedical Engineering, Tohoku University, 4-1 Seiryo, Aoba, Sendai, 980-8575 Japan

Biomedical Engineering Cancer Research Center, Graduate School of Biomedical Engineering, Tohoku University, 4-1 Seiryo, Aoba, Sendai, 980-8575 Japan

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Junnosuke Okajima,

Junnosuke Okajima

Institute of Fluid Science, Tohoku University, 2-1-1 Katahira, Aoba, Sendai, 980-8577 Japan

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Atsuki Komiya,

Atsuki Komiya

Institute of Fluid Science, Tohoku University, 2-1-1 Katahira, Aoba, Sendai, 980-8577 Japan

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Oluwatobi Oluwafemi,

Oluwatobi Oluwafemi

Department of Applied Chemistry, University of Johannesburg, Doornfontein Campus P.O. Box 17011, Doornfontein, 2028 South Africa

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Shigenao Maruyama,

Shigenao Maruyama

Institute of Fluid Science, Tohoku University, 2-1-1 Katahira, Aoba, Sendai, 980-8577 Japan

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Shiro Mori,

Shiro Mori

& Fax: +81-22-717-7583

Laboratory of Biomedical Engineering for Cancer, Department of Biomedical Engineering, Graduate School of Biomedical Engineering, Tohoku University, 4-1 Seiryo, Aoba, Sendai, 980-8575 Japan

Biomedical Engineering Cancer Research Center, Graduate School of Biomedical Engineering, Tohoku University, 4-1 Seiryo, Aoba, Sendai, 980-8575 Japan

Department of Oral and Maxillofacial Surgery, Tohoku University Hospital, 1-1 Seiryo, Aoba, Sendai, 980-8575 Japan

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Tetsuya Kodama,

Corresponding Author

Tetsuya Kodama

[email protected]
& Fax: +81-22-717-7583

Laboratory of Biomedical Engineering for Cancer, Department of Biomedical Engineering, Graduate School of Biomedical Engineering, Tohoku University, 4-1 Seiryo, Aoba, Sendai, 980-8575 Japan

Biomedical Engineering Cancer Research Center, Graduate School of Biomedical Engineering, Tohoku University, 4-1 Seiryo, Aoba, Sendai, 980-8575 Japan

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Daisuke Matsuki,

Daisuke Matsuki

Laboratory of Biomedical Engineering for Cancer, Department of Biomedical Engineering, Graduate School of Biomedical Engineering, Tohoku University, 4-1 Seiryo, Aoba, Sendai, 980-8575 Japan

Biomedical Engineering Cancer Research Center, Graduate School of Biomedical Engineering, Tohoku University, 4-1 Seiryo, Aoba, Sendai, 980-8575 Japan

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Oladipo Adewale,

Oladipo Adewale

Department of Applied Chemistry, University of Johannesburg, Doornfontein Campus P.O. Box 17011, Doornfontein, 2028 South Africa

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Sachiko Horie,

Sachiko Horie

Laboratory of Biomedical Engineering for Cancer, Department of Biomedical Engineering, Graduate School of Biomedical Engineering, Tohoku University, 4-1 Seiryo, Aoba, Sendai, 980-8575 Japan

Biomedical Engineering Cancer Research Center, Graduate School of Biomedical Engineering, Tohoku University, 4-1 Seiryo, Aoba, Sendai, 980-8575 Japan

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Junnosuke Okajima,

Junnosuke Okajima

Institute of Fluid Science, Tohoku University, 2-1-1 Katahira, Aoba, Sendai, 980-8577 Japan

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Atsuki Komiya,

Atsuki Komiya

Institute of Fluid Science, Tohoku University, 2-1-1 Katahira, Aoba, Sendai, 980-8577 Japan

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Oluwatobi Oluwafemi,

Oluwatobi Oluwafemi

Department of Applied Chemistry, University of Johannesburg, Doornfontein Campus P.O. Box 17011, Doornfontein, 2028 South Africa

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Shigenao Maruyama,

Shigenao Maruyama

Institute of Fluid Science, Tohoku University, 2-1-1 Katahira, Aoba, Sendai, 980-8577 Japan

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Shiro Mori,

Shiro Mori

& Fax: +81-22-717-7583

Laboratory of Biomedical Engineering for Cancer, Department of Biomedical Engineering, Graduate School of Biomedical Engineering, Tohoku University, 4-1 Seiryo, Aoba, Sendai, 980-8575 Japan

Biomedical Engineering Cancer Research Center, Graduate School of Biomedical Engineering, Tohoku University, 4-1 Seiryo, Aoba, Sendai, 980-8575 Japan

Department of Oral and Maxillofacial Surgery, Tohoku University Hospital, 1-1 Seiryo, Aoba, Sendai, 980-8575 Japan

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Tetsuya Kodama,

Corresponding Author

Tetsuya Kodama

[email protected]
& Fax: +81-22-717-7583

Laboratory of Biomedical Engineering for Cancer, Department of Biomedical Engineering, Graduate School of Biomedical Engineering, Tohoku University, 4-1 Seiryo, Aoba, Sendai, 980-8575 Japan

Biomedical Engineering Cancer Research Center, Graduate School of Biomedical Engineering, Tohoku University, 4-1 Seiryo, Aoba, Sendai, 980-8575 Japan

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First published: 18 April 2017

https://doi.org/10.1002/jbio.201600241

Citations: 10

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Abstract

Tumor metastasis to lymph nodes is an important contributory factor for cancer-related deaths despite recent developments in cancer therapy. In this study, we demonstrate that tumor in the proper axillary lymph node (PALN) of the mouse can be treated by the application of external laser light to trigger the unloading of doxorubicin (DOX) encapsulated in thermosensitive liposomes (TSLs) administered together with gold nanorods (GNRs). GNRs + DOX-TSLs were injected into a mouse lymph node containing cancer cells (malignant fibrous histiocytoma-like cells) and intranodal DOX release was activated using near-infrared (NIR) laser irradiation. The temperature changes arising from the laser-irradiated GNRs triggered the release of DOX from the TSLs. A greater degree of inhibition of tumor growth was found in the co-therapy group compared to the other groups. The treatment effect was achieved by a combination of chemotherapy and NIR-activated hyperthermia. In vivo bioluminescence imaging and histological analysis confirmed tumor necrosis in response to combined treatment. This work presents a theranostic approach with excellent treatment results that has the potential to be developed into an alternative to surgery for the treatment of breast cancer metastasis.

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Volume10, Issue12

Special Issue:Special Topic: Biophotonics in China

December 2017

Pages 1676-1682

Treatment of tumor in lymph nodes using near-infrared laser light-activated thermosensitive liposome-encapsulated doxorubicin and gold nanorods

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Treatment of tumor in lymph nodes using near-infrared laser light-activated thermosensitive liposome-encapsulated doxorubicin and gold nanorods

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