Ex vivo optical measurements of glucose diffusion kinetics in native and diabetic mouse skin
Corresponding Author
Daria K. Tuchina
- [email protected]
- +79042404134
Britton Chance Center for Biomedical Photonics, Wuhan National Laboratory for Optoelectronics, Huazhong University of Science and Technology, Wuhan, 430074 China
Research-Educational Institute of Optics and Biophotonics, Saratov State University, Saratov, 410012 Russia
Corresponding author: E-mail: [email protected], Phone: +7(8452)210716
Search for more papers by this authorRui Shi
Britton Chance Center for Biomedical Photonics, Wuhan National Laboratory for Optoelectronics, Huazhong University of Science and Technology, Wuhan, 430074 China
Search for more papers by this authorAlexey N. Bashkatov
Research-Educational Institute of Optics and Biophotonics, Saratov State University, Saratov, 410012 Russia
Interdisciplinary Laboratory of Biophotonics, Tomsk State University, Tomsk, 634050 Russia
Search for more papers by this authorElina A. Genina
Research-Educational Institute of Optics and Biophotonics, Saratov State University, Saratov, 410012 Russia
Interdisciplinary Laboratory of Biophotonics, Tomsk State University, Tomsk, 634050 Russia
Search for more papers by this authorDan Zhu
Britton Chance Center for Biomedical Photonics, Wuhan National Laboratory for Optoelectronics, Huazhong University of Science and Technology, Wuhan, 430074 China
Search for more papers by this authorQingming Luo
Britton Chance Center for Biomedical Photonics, Wuhan National Laboratory for Optoelectronics, Huazhong University of Science and Technology, Wuhan, 430074 China
Search for more papers by this authorValery V. Tuchin
Britton Chance Center for Biomedical Photonics, Wuhan National Laboratory for Optoelectronics, Huazhong University of Science and Technology, Wuhan, 430074 China
Research-Educational Institute of Optics and Biophotonics, Saratov State University, Saratov, 410012 Russia
Interdisciplinary Laboratory of Biophotonics, Tomsk State University, Tomsk, 634050 Russia
Search for more papers by this authorCorresponding Author
Daria K. Tuchina
- [email protected]
- +79042404134
Britton Chance Center for Biomedical Photonics, Wuhan National Laboratory for Optoelectronics, Huazhong University of Science and Technology, Wuhan, 430074 China
Research-Educational Institute of Optics and Biophotonics, Saratov State University, Saratov, 410012 Russia
Corresponding author: E-mail: [email protected], Phone: +7(8452)210716
Search for more papers by this authorRui Shi
Britton Chance Center for Biomedical Photonics, Wuhan National Laboratory for Optoelectronics, Huazhong University of Science and Technology, Wuhan, 430074 China
Search for more papers by this authorAlexey N. Bashkatov
Research-Educational Institute of Optics and Biophotonics, Saratov State University, Saratov, 410012 Russia
Interdisciplinary Laboratory of Biophotonics, Tomsk State University, Tomsk, 634050 Russia
Search for more papers by this authorElina A. Genina
Research-Educational Institute of Optics and Biophotonics, Saratov State University, Saratov, 410012 Russia
Interdisciplinary Laboratory of Biophotonics, Tomsk State University, Tomsk, 634050 Russia
Search for more papers by this authorDan Zhu
Britton Chance Center for Biomedical Photonics, Wuhan National Laboratory for Optoelectronics, Huazhong University of Science and Technology, Wuhan, 430074 China
Search for more papers by this authorQingming Luo
Britton Chance Center for Biomedical Photonics, Wuhan National Laboratory for Optoelectronics, Huazhong University of Science and Technology, Wuhan, 430074 China
Search for more papers by this authorValery V. Tuchin
Britton Chance Center for Biomedical Photonics, Wuhan National Laboratory for Optoelectronics, Huazhong University of Science and Technology, Wuhan, 430074 China
Research-Educational Institute of Optics and Biophotonics, Saratov State University, Saratov, 410012 Russia
Interdisciplinary Laboratory of Biophotonics, Tomsk State University, Tomsk, 634050 Russia
Search for more papers by this authorAbstract
The aim of this study was to estimate the glucose diffusion coefficients ex vivo in skin of mice with diabetes induced in vivo by alloxan in comparison to non-diabetic mice. The temporal dependences of collimated transmittance of tissue samples immersed in glucose solutions were measured in the VIS-NIR spectral range to quantify the glucose diffusion/permeability coefficients and optical clearing efficiency of mouse skin. The average thickness of intact healthy and diabetic skin was 0.023 ± 0.006 cm and 0.019 ± 0.005 cm, respectively. Considerable differences in optical and kinetic properties of diabetic and non-diabetic skin were found: clearing efficiency was 1.5-fold better and glucose diffusivity was 2-fold slower for diabetic skin.
Experimental Setup for measuring collimated transmittance spectra of mouse skin samples.
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