Investigation of the permeability and optical clearing ability of different analytes in human normal and cancerous breast tissues by spectral domain OCT
Zhenguo Zhu
MOE Key Laboratory of Laser Life Science & Institute of Laser Life Science, College of Biophotonics, South China Normal University, Guangzhou 510631, China
Search for more papers by this authorGuoyong Wu
Department of Surgery, the First Affiliated Hospital, Sun Yat-Sen University, Guangzhou 510080, Guangdong Province, China
Search for more papers by this authorCorresponding Author
Huajiang Wei
MOE Key Laboratory of Laser Life Science & Institute of Laser Life Science, College of Biophotonics, South China Normal University, Guangzhou 510631, China
Phone: 86-020-85216052, Fax: 86-020-85216052Search for more papers by this authorHongqin Yang
Key Laboratory of Optoelectronic Science and Technology for Medicine of Ministry of Education of China, Fujian Normal University, Fuzhou 350007, Fujian, China
Search for more papers by this authorYonghong He
Graduate School at Shenzhen, Tsinghua University, Shenzhen 518055, Guangdong, China
Search for more papers by this authorShusen Xie
Key Laboratory of Optoelectronic Science and Technology for Medicine of Ministry of Education of China, Fujian Normal University, Fuzhou 350007, Fujian, China
Search for more papers by this authorQingliang Zhao
MOE Key Laboratory of Laser Life Science & Institute of Laser Life Science, College of Biophotonics, South China Normal University, Guangzhou 510631, China
Search for more papers by this authorXiao Guo
MOE Key Laboratory of Laser Life Science & Institute of Laser Life Science, College of Biophotonics, South China Normal University, Guangzhou 510631, China
Search for more papers by this authorZhenguo Zhu
MOE Key Laboratory of Laser Life Science & Institute of Laser Life Science, College of Biophotonics, South China Normal University, Guangzhou 510631, China
Search for more papers by this authorGuoyong Wu
Department of Surgery, the First Affiliated Hospital, Sun Yat-Sen University, Guangzhou 510080, Guangdong Province, China
Search for more papers by this authorCorresponding Author
Huajiang Wei
MOE Key Laboratory of Laser Life Science & Institute of Laser Life Science, College of Biophotonics, South China Normal University, Guangzhou 510631, China
Phone: 86-020-85216052, Fax: 86-020-85216052Search for more papers by this authorHongqin Yang
Key Laboratory of Optoelectronic Science and Technology for Medicine of Ministry of Education of China, Fujian Normal University, Fuzhou 350007, Fujian, China
Search for more papers by this authorYonghong He
Graduate School at Shenzhen, Tsinghua University, Shenzhen 518055, Guangdong, China
Search for more papers by this authorShusen Xie
Key Laboratory of Optoelectronic Science and Technology for Medicine of Ministry of Education of China, Fujian Normal University, Fuzhou 350007, Fujian, China
Search for more papers by this authorQingliang Zhao
MOE Key Laboratory of Laser Life Science & Institute of Laser Life Science, College of Biophotonics, South China Normal University, Guangzhou 510631, China
Search for more papers by this authorXiao Guo
MOE Key Laboratory of Laser Life Science & Institute of Laser Life Science, College of Biophotonics, South China Normal University, Guangzhou 510631, China
Search for more papers by this authorAbstract
The potential of OCT applied for early breast cancer detection attracted significant efforts. The permeability coefficients and the percentages of OCT signal enhancement for normal and cancerous breast tissues have been investigated from the experiments of 20% glucose, 40% glucose, and 20% mannitol in vitro. Obtained results indicate that the permeability coefficient in breast cancer tissue is prominently larger than that in normal breast tissue, while the optical clearing effect is just the reverse to that for each agent. The results suggest that OCT has the ability to distinguish cancer tissue from different aspect. (© 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim)
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