Electrochemical hydrogen production is considered as one of the most significant ways to develop clean energy in the future. Herein, the self-supporting electrocatalyst of MoS₂@Ni(Mn)VO _X is fabricated on 3D nickel foam (NF) by a facile two-step electrodeposition approach. The optimal MoS₂@Ni(Mn)VO _X electrode shows an ultralow overpotential of 61 mV to achieve a current density of 10 mA cm⁻² and a Tafel slope of 35.1 mV dec⁻¹ in 1 m KOH, which is superior to NF, MoS₂@NF, NiVO _X , Ni(Mn)VO _X , or MoS₂@NiVO _X . The uniformly dispersed coral-shaped heterostructure exposes more active sites and makes the charge transfer rate faster. The outstanding synergistic effect of MoS₂ and transition metal oxides of Ni, Mn, and V also contribute to the enhanced activity of the catalyst. Benefiting from these, MoS₂@Ni(Mn)VO _X shows superior alkaline hydrogen evolution reaction activity and long-term stability. Herein, a novel catalyst for highly efficient hydrogen evolution in alkaline media is provided.