Concise Report
Rhodium-Catalyzed N-Arylation Addition of Arylboronic Acids to Ketimines
Xue-Wei Qian,
Xing-Wen Sun,
Xue-Wei Qian
Department of Chemistry, Fudan University, 220 Handan Road, Shanghai, 200433 China
Search for more papers by this authorCorresponding Author
Xing-Wen Sun
Department of Chemistry, Fudan University, 220 Handan Road, Shanghai, 200433 China
E-mail: [email protected]Search for more papers by this authorXue-Wei Qian,
Xing-Wen Sun,
Xue-Wei Qian
Department of Chemistry, Fudan University, 220 Handan Road, Shanghai, 200433 China
Search for more papers by this authorCorresponding Author
Xing-Wen Sun
Department of Chemistry, Fudan University, 220 Handan Road, Shanghai, 200433 China
E-mail: [email protected]Search for more papers by this authorComprehensive Summary
Herein, we report rhodium catalyzed N-arylation via addition of arylboronic acids to electron-deficient α-iminoesters which can be prepared in high efficiency by using easily accessible β-carbonyl esters. The reaction is highly regiospecific to achieve the N-aryl addition efficiently with up to 99% yield under mild conditions. The corresponding product can be further efficiently converted into indoles and a series of other important building blocks.
Supporting Information
| Filename | Description |
|---|---|
| CJOC202400208-sup-0001-supinfo.pdfPDF document, 10.4 MB |
Appendix S1: Supporting Information |
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