Palladium-Catalyzed Skeletal Reorganization of Cyclobutanones Invoving Successive C—C Bond/C—H Bond Cleavage
Ruirui Li
State Key Laboratory and Institute of Elemento-Organic Chemistry, College of Chemistry, Nankai University, Tianjin, 300071 China
These authors contributed equally to this work.
Search for more papers by this authorXiaonan Shi
State Key Laboratory and Institute of Elemento-Organic Chemistry, College of Chemistry, Nankai University, Tianjin, 300071 China
These authors contributed equally to this work.
Search for more papers by this authorCorresponding Author
Dongbing Zhao
State Key Laboratory and Institute of Elemento-Organic Chemistry, College of Chemistry, Nankai University, Tianjin, 300071 China
E-mail: [email protected]Search for more papers by this authorRuirui Li
State Key Laboratory and Institute of Elemento-Organic Chemistry, College of Chemistry, Nankai University, Tianjin, 300071 China
These authors contributed equally to this work.
Search for more papers by this authorXiaonan Shi
State Key Laboratory and Institute of Elemento-Organic Chemistry, College of Chemistry, Nankai University, Tianjin, 300071 China
These authors contributed equally to this work.
Search for more papers by this authorCorresponding Author
Dongbing Zhao
State Key Laboratory and Institute of Elemento-Organic Chemistry, College of Chemistry, Nankai University, Tianjin, 300071 China
E-mail: [email protected]Search for more papers by this authorComprehensive Summary
The utilization of cyclobutanones as the synthon in transition metal catalysis has been made great success. Because C(carbonyl)−C bond of cyclobutanones can be cleaved through strain release. Despite those advancements, the main catalysts in literature are Rh catalysts or Ni catalysts and the reaction with C—H bond is still underdeveloped. Herein, we realized the first palladium-catalyzed skeletal reorganization of cyclobutanones involving successive cleavage of C(carbonyl)−C bonds and C—H bond cleavage, which constitutes an rapid access to diverse indanones. In contrast to the previous Rh-catalytic system, the Pd-catalytic system herein involves different mechanism and features several advantages: 1) no need of directing group to facilitate the C(carbonyl)−C bond cleavage; 2) much milder reaction condition and 3) simplified work-up.
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