HPDA/Zn as a CREB Inhibitor for Ultrasound Imaging and Stabilization of Atherosclerosis Plaque†
Correction(s) for this article
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Corrigendum
- Volume 41Issue 6Chinese Journal of Chemistry
- pages: 741-741
- First Published online: February 15, 2023
Linzi Chen
Ningbo Yinzhou No.2 Hospital, Ningbo, Zhejiang, 315192 China
‡ These authors contributed equally to this work.
† Dedicated to Professor Erkang Wang on the Occasion of His 90th Birthday.
Search for more papers by this authorZhenqi Jiang
Cixi Institute of Biomedical Engineering, International Cooperation Base of Biomedical Materials Technology and Application, CAS Key Laboratory of Magnetic Materials and Devices, Zhejiang Engineering Research Center for Biomedical Materials, Ningbo Institute of Materials Technology and Engineering, Chinese Academy of Sciences, Ningbo, Zhejiang, 315201 China
School of Medical Technology, Institute of Engineering Medicine, Beijing Institute of Technology, Beijing, 100081 China
‡ These authors contributed equally to this work.
† Dedicated to Professor Erkang Wang on the Occasion of His 90th Birthday.
Search for more papers by this authorLifei Yang
Ningbo Yinzhou No.2 Hospital, Ningbo, Zhejiang, 315192 China
‡ These authors contributed equally to this work.
† Dedicated to Professor Erkang Wang on the Occasion of His 90th Birthday.
Search for more papers by this authorYe Fang
Ningbo Yinzhou No.2 Hospital, Ningbo, Zhejiang, 315192 China
Search for more papers by this authorShuwei Lu
Ningbo Yinzhou No.2 Hospital, Ningbo, Zhejiang, 315192 China
Search for more papers by this authorOzioma U. Akakuru
Cixi Institute of Biomedical Engineering, International Cooperation Base of Biomedical Materials Technology and Application, CAS Key Laboratory of Magnetic Materials and Devices, Zhejiang Engineering Research Center for Biomedical Materials, Ningbo Institute of Materials Technology and Engineering, Chinese Academy of Sciences, Ningbo, Zhejiang, 315201 China
Search for more papers by this authorShuaishuai Huang
Ningbo Yinzhou No.2 Hospital, Ningbo, Zhejiang, 315192 China
Search for more papers by this authorCorresponding Author
Juan Li
Cixi Institute of Biomedical Engineering, International Cooperation Base of Biomedical Materials Technology and Application, CAS Key Laboratory of Magnetic Materials and Devices, Zhejiang Engineering Research Center for Biomedical Materials, Ningbo Institute of Materials Technology and Engineering, Chinese Academy of Sciences, Ningbo, Zhejiang, 315201 China
E-mail: [email protected]; [email protected]; [email protected]Search for more papers by this authorCorresponding Author
Suya Ma
Ningbo Yinzhou No.2 Hospital, Ningbo, Zhejiang, 315192 China
E-mail: [email protected]; [email protected]; [email protected]Search for more papers by this authorCorresponding Author
Aiguo Wu
Cixi Institute of Biomedical Engineering, International Cooperation Base of Biomedical Materials Technology and Application, CAS Key Laboratory of Magnetic Materials and Devices, Zhejiang Engineering Research Center for Biomedical Materials, Ningbo Institute of Materials Technology and Engineering, Chinese Academy of Sciences, Ningbo, Zhejiang, 315201 China
E-mail: [email protected]; [email protected]; [email protected]Search for more papers by this authorLinzi Chen
Ningbo Yinzhou No.2 Hospital, Ningbo, Zhejiang, 315192 China
‡ These authors contributed equally to this work.
† Dedicated to Professor Erkang Wang on the Occasion of His 90th Birthday.
Search for more papers by this authorZhenqi Jiang
Cixi Institute of Biomedical Engineering, International Cooperation Base of Biomedical Materials Technology and Application, CAS Key Laboratory of Magnetic Materials and Devices, Zhejiang Engineering Research Center for Biomedical Materials, Ningbo Institute of Materials Technology and Engineering, Chinese Academy of Sciences, Ningbo, Zhejiang, 315201 China
School of Medical Technology, Institute of Engineering Medicine, Beijing Institute of Technology, Beijing, 100081 China
‡ These authors contributed equally to this work.
† Dedicated to Professor Erkang Wang on the Occasion of His 90th Birthday.
Search for more papers by this authorLifei Yang
Ningbo Yinzhou No.2 Hospital, Ningbo, Zhejiang, 315192 China
‡ These authors contributed equally to this work.
† Dedicated to Professor Erkang Wang on the Occasion of His 90th Birthday.
Search for more papers by this authorYe Fang
Ningbo Yinzhou No.2 Hospital, Ningbo, Zhejiang, 315192 China
Search for more papers by this authorShuwei Lu
Ningbo Yinzhou No.2 Hospital, Ningbo, Zhejiang, 315192 China
Search for more papers by this authorOzioma U. Akakuru
Cixi Institute of Biomedical Engineering, International Cooperation Base of Biomedical Materials Technology and Application, CAS Key Laboratory of Magnetic Materials and Devices, Zhejiang Engineering Research Center for Biomedical Materials, Ningbo Institute of Materials Technology and Engineering, Chinese Academy of Sciences, Ningbo, Zhejiang, 315201 China
Search for more papers by this authorShuaishuai Huang
Ningbo Yinzhou No.2 Hospital, Ningbo, Zhejiang, 315192 China
Search for more papers by this authorCorresponding Author
Juan Li
Cixi Institute of Biomedical Engineering, International Cooperation Base of Biomedical Materials Technology and Application, CAS Key Laboratory of Magnetic Materials and Devices, Zhejiang Engineering Research Center for Biomedical Materials, Ningbo Institute of Materials Technology and Engineering, Chinese Academy of Sciences, Ningbo, Zhejiang, 315201 China
E-mail: [email protected]; [email protected]; [email protected]Search for more papers by this authorCorresponding Author
Suya Ma
Ningbo Yinzhou No.2 Hospital, Ningbo, Zhejiang, 315192 China
E-mail: [email protected]; [email protected]; [email protected]Search for more papers by this authorCorresponding Author
Aiguo Wu
Cixi Institute of Biomedical Engineering, International Cooperation Base of Biomedical Materials Technology and Application, CAS Key Laboratory of Magnetic Materials and Devices, Zhejiang Engineering Research Center for Biomedical Materials, Ningbo Institute of Materials Technology and Engineering, Chinese Academy of Sciences, Ningbo, Zhejiang, 315201 China
E-mail: [email protected]; [email protected]; [email protected]Search for more papers by this authorComprehensive Summary
Thrombosis, secondary to rupture of unstable plaque, is a fatal risk factor for myocardial infarction and ischemic stroke. At present, more novel methods are needed for the diagnosis and treatment of vulnerable plaque. Here, we report a hollow polydopamine/Zn (HPDA/Zn) ultrasound contrast agent. Through western-blot, Elisa, and other experiments, we found that in addition to having a good contrast-enhancement capability in ultrasound imaging in vitro and in vivo, HPDA/Zn also has the effect of reducing the expression of CREB. CREB protein and its downstream-regulated proteins and factors are closely related to the stability of plaque. HPDA/Zn has the effect of reducing the expression of CREB protein, which leads to the decrease of expression of MMP-9, the regulatory protein downstream of the CREB protein. In addition, it also reduces the secretion of inflammatory factors hs-CRP and IL-17A. Thus, HPDA/Zn can stabilize plaque by inhibiting CREB and reducing plaque vulnerable markers and inflammatory factors. In a word, HPDA/Zn is a kind of ultrasound contrast agent, which can stabilize plaques by inhibiting CREB protein.
Supporting Information
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Appendix S1: Supporting Information |
Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
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