Cover Picture
Free Access
Cover Picture: Synthesis of Osthole Derivatives with Grignard Reagents and Their Larvicidal Activities on Mosquitoes (Chin. J. Chem. 12/2015)
First published: 18 December 2015
Graphical Abstract
The cover picture showsan inexpensive and eco-friendly method to synthesize osthole derivatives with Grignard reagents assisted by CuI and LiCl. With the purpose of discovering novel insecticides from Traditional Chinese Medicine (TCM), the structure of osthole has been modified to improve its larvicidal activity against mosquitoes. Starting from Grignard reagents generated from 8-iodocoumarins, a broad range of osthole derivatives can be prepared in mild to good yields (up to 83%). Bio-activity evaluation showed that several products exhibited better larvicidal activities than osthole. More details are discussed in the article by Li et al. on page 1353–1358.
