Synthesis and Antiviral Activities of Chiral Thiourea Derivatives
Zhikun YAN
Center for Research and Development of Fine Chemicals, Education Ministry Key Laboratory of Green Pesticide and Agricultural Bioengineering, Guizhou University, Guizhou, Guiyang 550025, China
Search for more papers by this authorXuejian CAI
Center for Research and Development of Fine Chemicals, Education Ministry Key Laboratory of Green Pesticide and Agricultural Bioengineering, Guizhou University, Guizhou, Guiyang 550025, China
Search for more papers by this authorXuan YANG
Center for Research and Development of Fine Chemicals, Education Ministry Key Laboratory of Green Pesticide and Agricultural Bioengineering, Guizhou University, Guizhou, Guiyang 550025, China
Search for more papers by this authorZhuo CHEN
Center for Research and Development of Fine Chemicals, Education Ministry Key Laboratory of Green Pesticide and Agricultural Bioengineering, Guizhou University, Guizhou, Guiyang 550025, China
Search for more papers by this authorS. Pinaki BHADURY
Center for Research and Development of Fine Chemicals, Education Ministry Key Laboratory of Green Pesticide and Agricultural Bioengineering, Guizhou University, Guizhou, Guiyang 550025, China
Search for more papers by this authorDeyu HU
Center for Research and Development of Fine Chemicals, Education Ministry Key Laboratory of Green Pesticide and Agricultural Bioengineering, Guizhou University, Guizhou, Guiyang 550025, China
Search for more papers by this authorLinhong JIN
Center for Research and Development of Fine Chemicals, Education Ministry Key Laboratory of Green Pesticide and Agricultural Bioengineering, Guizhou University, Guizhou, Guiyang 550025, China
Search for more papers by this authorWei XUE
Center for Research and Development of Fine Chemicals, Education Ministry Key Laboratory of Green Pesticide and Agricultural Bioengineering, Guizhou University, Guizhou, Guiyang 550025, China
Search for more papers by this authorPing LU
Center for Research and Development of Fine Chemicals, Education Ministry Key Laboratory of Green Pesticide and Agricultural Bioengineering, Guizhou University, Guizhou, Guiyang 550025, China
Search for more papers by this authorZhikun YAN
Center for Research and Development of Fine Chemicals, Education Ministry Key Laboratory of Green Pesticide and Agricultural Bioengineering, Guizhou University, Guizhou, Guiyang 550025, China
Search for more papers by this authorXuejian CAI
Center for Research and Development of Fine Chemicals, Education Ministry Key Laboratory of Green Pesticide and Agricultural Bioengineering, Guizhou University, Guizhou, Guiyang 550025, China
Search for more papers by this authorXuan YANG
Center for Research and Development of Fine Chemicals, Education Ministry Key Laboratory of Green Pesticide and Agricultural Bioengineering, Guizhou University, Guizhou, Guiyang 550025, China
Search for more papers by this authorZhuo CHEN
Center for Research and Development of Fine Chemicals, Education Ministry Key Laboratory of Green Pesticide and Agricultural Bioengineering, Guizhou University, Guizhou, Guiyang 550025, China
Search for more papers by this authorS. Pinaki BHADURY
Center for Research and Development of Fine Chemicals, Education Ministry Key Laboratory of Green Pesticide and Agricultural Bioengineering, Guizhou University, Guizhou, Guiyang 550025, China
Search for more papers by this authorDeyu HU
Center for Research and Development of Fine Chemicals, Education Ministry Key Laboratory of Green Pesticide and Agricultural Bioengineering, Guizhou University, Guizhou, Guiyang 550025, China
Search for more papers by this authorLinhong JIN
Center for Research and Development of Fine Chemicals, Education Ministry Key Laboratory of Green Pesticide and Agricultural Bioengineering, Guizhou University, Guizhou, Guiyang 550025, China
Search for more papers by this authorWei XUE
Center for Research and Development of Fine Chemicals, Education Ministry Key Laboratory of Green Pesticide and Agricultural Bioengineering, Guizhou University, Guizhou, Guiyang 550025, China
Search for more papers by this authorPing LU
Center for Research and Development of Fine Chemicals, Education Ministry Key Laboratory of Green Pesticide and Agricultural Bioengineering, Guizhou University, Guizhou, Guiyang 550025, China
Search for more papers by this authorAbstract
An environmentally benign method has been developed for the synthesis of novel chiral thiourea derivatives in high yields in ionic liquid [Bmim]PF6. The ionic solvent can be recovered and reused without any loss of its activity. The target compounds were characterized by elemental analysis, IR, 1H NMR and 13C NMR spectral data. According to the preliminary bioassay, some of the chiral thiourea analogues exhibited moderate in vivo antiviral activities against TMV at a concentration of 500 mg/L. Title chiral compound 3i was found to possess good in vivo protection, inactivation and curative activities of 57.0%, 96.4% and 55.0%, respectively against TMV with an inhibitory concentration at 500 mg/L. The title chiral compound 3i revealed better inactivation effect on TMV (EC50=50.8 µg/mL) than Ningnanmycin (EC50=60.2 µg/mL).
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