Ionic liquid-H2O Resulting in a Highly Chemoselective Oxidation of Benzylic Alcohols in the Presence of Aliphatic Analogues Catalyzed by Immobilized TEMPO
Ruijun HU
Department of Chemistry, Zhejiang University, Hangzhou, Zhejiang 310027, China
Search for more papers by this authorHegeng WEI
Department of Chemistry, Zhejiang University, Hangzhou, Zhejiang 310027, China
Search for more papers by this authorYanguang WANG
Department of Chemistry, Zhejiang University, Hangzhou, Zhejiang 310027, China
Search for more papers by this authorRuijun HU
Department of Chemistry, Zhejiang University, Hangzhou, Zhejiang 310027, China
Search for more papers by this authorHegeng WEI
Department of Chemistry, Zhejiang University, Hangzhou, Zhejiang 310027, China
Search for more papers by this authorYanguang WANG
Department of Chemistry, Zhejiang University, Hangzhou, Zhejiang 310027, China
Search for more papers by this authorAbstract
In ionic liquid 1-butyl-3-methylimidazolium hexafluorophosphate ([bmim][PF6])-H2O, a highly chemoselective oxidation of benzylic alcohols in the presence of aliphatic ones to the corresponding hydroxyl benzyl aldehydes and ketones was allowed in high yields using N-chlorosuccinimide (NCS)/NaBr/IL-TEMPO (ionic liquid immobilized 2,2,6,6-tetramethylpiperidine-1-oxyl) as a facile and effective catalytic oxidation system. The medium, [bmim][PF6], together with the catalyst IL-TEMPO could be easily recycled for ten runs without any influence on the efficacy of the reaction in terms of yield and selectivity of the product.
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