Synthesis and Biological Activities of Novel Thiophosphoryl Oximates Containing Thiazole and 1,2,3-Triazole Rings

In order to find novel high activity and low toxicity agrochemicals, a series of novel thiophosphoryl oximates containing thiazole and 1,2,3-triazole rings 4 were synthesized by the reactions of 1-{1-[(2-chlorothiazol-5- yl)methyl]-5-methyl-1H-1,2,3-triazol-4-yl}ethanone oxime with various asymmetric thiophosphoryl chlorides. Their structures were confirmed by IR, ¹H NMR, ³¹P NMR, EI-MS and elemental analyses. The target compounds existed as E-configuration, which was deduced by NMR analysis and by comparison with their pyridyl analog determined by X-ray diffraction. The results of preliminary bioassay indicate that some of title compounds possess moderate insecticidal and fungicidal activities.