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Stereoselective binding of benzodiazepines and related compounds on calmodulin-sepharose
Ilona Fitos,
Jüalia Visy,
Julianna Kardos,
Miklóas Simonyi,
Corresponding Author
Ilona Fitos
Central Research Institute for Chemistry, The Hungarian Academy of Sciences, Budapest, Hungary
Central Research Institute for Chemistry, The Hungarian Academy of Sciences, P.O. Box 17, H-1525 Budapest, HungarySearch for more papers by this authorJüalia Visy
Central Research Institute for Chemistry, The Hungarian Academy of Sciences, Budapest, Hungary
Search for more papers by this authorJulianna Kardos
Central Research Institute for Chemistry, The Hungarian Academy of Sciences, Budapest, Hungary
Search for more papers by this authorMiklóas Simonyi
Central Research Institute for Chemistry, The Hungarian Academy of Sciences, Budapest, Hungary
Search for more papers by this authorIlona Fitos,
Jüalia Visy,
Julianna Kardos,
Miklóas Simonyi,
Corresponding Author
Ilona Fitos
Central Research Institute for Chemistry, The Hungarian Academy of Sciences, Budapest, Hungary
Central Research Institute for Chemistry, The Hungarian Academy of Sciences, P.O. Box 17, H-1525 Budapest, HungarySearch for more papers by this authorJüalia Visy
Central Research Institute for Chemistry, The Hungarian Academy of Sciences, Budapest, Hungary
Search for more papers by this authorJulianna Kardos
Central Research Institute for Chemistry, The Hungarian Academy of Sciences, Budapest, Hungary
Search for more papers by this authorMiklóas Simonyi
Central Research Institute for Chemistry, The Hungarian Academy of Sciences, Budapest, Hungary
Search for more papers by this authorAbstract
A method has been presented to evaluate the Ca2+-dependent binding affinity of ligands to calmodulin (CaM) from their chromatographic retentions obtained on a CaM-Sepharose column. Enantiomers of benzodiazepines and related compounds could be separated. Among chiral calcium antagonists, verapamil showed stereoselectivity of binding. © 1995 Wiley-Liss, Inc.
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