Volume 21, Issue 6 e202400524
Research Article

Two New Phenylpropanoid Compounds from Lilium Brownii and Their Anti-monoamine Oxidase Activity

Chengcheng Hui

Chengcheng Hui

Department of Pharmacy, Henan University of Chinese Medicine, Zhengzhou, 450046 China Tel

Henan Engineering Research Center of Medicinal and Edible Chinese Medicine, Zhengzhou, 450046 China

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Shuaibo He

Shuaibo He

Department of Pharmacy, Henan University of Chinese Medicine, Zhengzhou, 450046 China Tel

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Mengshan Ji

Mengshan Ji

Department of Pharmacy, Henan University of Chinese Medicine, Zhengzhou, 450046 China Tel

Henan Engineering Research Center of Medicinal and Edible Chinese Medicine, Zhengzhou, 450046 China

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Yuhang Zhang

Yuhang Zhang

The Second Clinical Medical College, Henan University of Chinese Medicine, Zhengzhou, 450046 China

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Haibo Wang

Haibo Wang

NMPA Key Laboratory for Quality Control of Traditional Chinese Medicine (Chinese Materia Medica and prepared slices), Henan Institute for Drug and Medical Device Inspection (Henan Vaccine Issuance Center), Zhengzhou, 450018 China

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Xiaowei Wang

Xiaowei Wang

NMPA Key Laboratory for Quality Control of Traditional Chinese Medicine (Chinese Materia Medica and prepared slices), Henan Institute for Drug and Medical Device Inspection (Henan Vaccine Issuance Center), Zhengzhou, 450018 China

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Tao Guo

Corresponding Author

Tao Guo

Department of Pharmacy, Henan University of Chinese Medicine, Zhengzhou, 450046 China Tel

Henan Engineering Research Center of Medicinal and Edible Chinese Medicine, Zhengzhou, 450046 China

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First published: 18 April 2024

Abstract

Baihe is a commonly used Chinese medicine for the treatment of neurological disorders. Clinically, the bulbs of Lilium brownii are used to act as Baihe. In the study, two new phenylpropanoid compounds including 3-O-acetyl-1-O-caffeoylglycerol (1) and 3-O-acetyl-1-O-p-coumaroylglycerol (2) were isolated from the bulbs of L. brownii. Their structures were identified by spectroscopic method and the effect on monoamine oxidase activity was determined using an enzyme labeling method. The results show 1 and 2 have anti-monoamine oxidase activity with 20.96 % and 22.31 % inhibition rates at 50 μg/ml, respectively.

Graphical Abstract

Conflict of interests

The authors declare no conflict of interest.

Data Availability Statement

The data that support the findings of this study are available from the corresponding author upon reasonable request.

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