A New Alkaloid from the Aerial Parts of Bupleurum chinense DC.
Zong-Yu Xiao
Key Laboratory of Chinese Materia Medica, Heilongjiang University of Chinese Medicine, Ministry of Education, Harbin, 150040 P. R. China
Zong-Yu Xiao and Yan Liu contributed equally to this work.
Search for more papers by this authorYan Liu
Key Laboratory of Chinese Materia Medica, Heilongjiang University of Chinese Medicine, Ministry of Education, Harbin, 150040 P. R. China
Zong-Yu Xiao and Yan Liu contributed equally to this work.
Search for more papers by this authorYan-Ping Sun
Key Laboratory of Chinese Materia Medica, Heilongjiang University of Chinese Medicine, Ministry of Education, Harbin, 150040 P. R. China
Search for more papers by this authorYuan Liu
Key Laboratory of Chinese Materia Medica, Heilongjiang University of Chinese Medicine, Ministry of Education, Harbin, 150040 P. R. China
Search for more papers by this authorCorresponding Author
Bing-You Yang
Key Laboratory of Chinese Materia Medica, Heilongjiang University of Chinese Medicine, Ministry of Education, Harbin, 150040 P. R. China
Search for more papers by this authorCorresponding Author
Hai-Xue Kuang
Key Laboratory of Chinese Materia Medica, Heilongjiang University of Chinese Medicine, Ministry of Education, Harbin, 150040 P. R. China
Search for more papers by this authorZong-Yu Xiao
Key Laboratory of Chinese Materia Medica, Heilongjiang University of Chinese Medicine, Ministry of Education, Harbin, 150040 P. R. China
Zong-Yu Xiao and Yan Liu contributed equally to this work.
Search for more papers by this authorYan Liu
Key Laboratory of Chinese Materia Medica, Heilongjiang University of Chinese Medicine, Ministry of Education, Harbin, 150040 P. R. China
Zong-Yu Xiao and Yan Liu contributed equally to this work.
Search for more papers by this authorYan-Ping Sun
Key Laboratory of Chinese Materia Medica, Heilongjiang University of Chinese Medicine, Ministry of Education, Harbin, 150040 P. R. China
Search for more papers by this authorYuan Liu
Key Laboratory of Chinese Materia Medica, Heilongjiang University of Chinese Medicine, Ministry of Education, Harbin, 150040 P. R. China
Search for more papers by this authorCorresponding Author
Bing-You Yang
Key Laboratory of Chinese Materia Medica, Heilongjiang University of Chinese Medicine, Ministry of Education, Harbin, 150040 P. R. China
Search for more papers by this authorCorresponding Author
Hai-Xue Kuang
Key Laboratory of Chinese Materia Medica, Heilongjiang University of Chinese Medicine, Ministry of Education, Harbin, 150040 P. R. China
Search for more papers by this authorAbstract
A new isoalloxazine alkaloid, named bupleurine A (1), along with five known compounds (2–6), were isolated from the aerial parts of Bupleurum chinense DC. The structure elucidation of the new alkaloid (1) was employed by combining NMR and HR-MS data with comparison of reference in the literature. Five known compounds (2–6) were isolated from Bupleurum genus for the first time. Additionally, their antiproliferative activities on HeLa cells were evaluated by MTT assay and IC50 of compounds 1 and 4–6 were below 10 μm after treatment for 24 h.
Graphical Abstract
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