Polyhydrazide-Based Organic Nanotubes as Efficient and Selective Artificial Iodide Channels
Dr. Arundhati Roy
NanoBio Lab, 31 Biopolis Way, The Nanos, Singapore, 138669 Singapore
These authors contributed equally to this work.
Search for more papers by this authorDr. Himanshu Joshi
Department of Physics and Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, Urbana, IL, 61801 USA
These authors contributed equally to this work.
Search for more papers by this authorRuijuan Ye
Department of Chemical and Biomolecular Engineering, National University of Singapore, Singapore, 117585 Singapore
Search for more papers by this authorDr. Jie Shen
NanoBio Lab, 31 Biopolis Way, The Nanos, Singapore, 138669 Singapore
Search for more papers by this authorDr. Feng Chen
NanoBio Lab, 31 Biopolis Way, The Nanos, Singapore, 138669 Singapore
Search for more papers by this authorCorresponding Author
Prof. Dr. Aleksei Aksimentiev
Department of Physics and Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, Urbana, IL, 61801 USA
Search for more papers by this authorCorresponding Author
Dr. Huaqiang Zeng
NanoBio Lab, 31 Biopolis Way, The Nanos, Singapore, 138669 Singapore
Search for more papers by this authorDr. Arundhati Roy
NanoBio Lab, 31 Biopolis Way, The Nanos, Singapore, 138669 Singapore
These authors contributed equally to this work.
Search for more papers by this authorDr. Himanshu Joshi
Department of Physics and Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, Urbana, IL, 61801 USA
These authors contributed equally to this work.
Search for more papers by this authorRuijuan Ye
Department of Chemical and Biomolecular Engineering, National University of Singapore, Singapore, 117585 Singapore
Search for more papers by this authorDr. Jie Shen
NanoBio Lab, 31 Biopolis Way, The Nanos, Singapore, 138669 Singapore
Search for more papers by this authorDr. Feng Chen
NanoBio Lab, 31 Biopolis Way, The Nanos, Singapore, 138669 Singapore
Search for more papers by this authorCorresponding Author
Prof. Dr. Aleksei Aksimentiev
Department of Physics and Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, Urbana, IL, 61801 USA
Search for more papers by this authorCorresponding Author
Dr. Huaqiang Zeng
NanoBio Lab, 31 Biopolis Way, The Nanos, Singapore, 138669 Singapore
Search for more papers by this authorGraphical Abstract
The right channels: A novel class of foldamer-based pore-forming helically folded polyhydrazides, having hydrophobic cavities of about a 6.5 Å diameter, promote transport of anions, rather than cations, across membranes, with iodide as the preferred transport species. The best channel, having a helical height of 3.6 nm, exhibits the highest recorded iodide transport activity (EC50=0.042 μm or 0.028 mol % relative to lipid) and high I−/Cl− selectivity of 11, in terms of EC50 values, or 42 based on initial rate constants.
Abstract
Reported herein is a series of pore-containing polymeric nanotubes based on a hydrogen-bonded hydrazide backbone. Nanotubes of suitable lengths, possessing a hollow cavity of about a 6.5 Å diameter, mediate highly efficient transport of diverse types of anions, rather than cations, across lipid membranes. The reported polymer channel, having an average molecular weight of 18.2 kDa and 3.6 nm in helical height, exhibits the highest anion-transport activities for iodide (EC50=0.042 μm or 0.028 mol % relative to lipid), whcih is transported 10 times more efficiently than chlorides (EC50=0.47 μm). Notably, even in cholesterol-rich environment, iodide transport activity remains high with an EC50 of 0.37 μm. Molecular dynamics simulation studies confirm that the channel is highly selective for anions and that such anion selectivity arises from a positive electrostatic potential of the central lumen rendered by the interior-pointing methyl groups.
Conflict of interest
The authors declare no conflict of interest.
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