Regioselective Hydrohydroxyalkylation of Styrene with Primary Alcohols or Aldehydes via Ruthenium-Catalyzed C−C Bond Forming Transfer Hydrogenation
Hongde Xiao
University of Texas at Austin, Department of Chemistry, 105 E 24th St. A5300, Austin, TX, 78712-1167 USA
These authors contributed equally to this work.
Search for more papers by this authorGang Wang
University of Texas at Austin, Department of Chemistry, 105 E 24th St. A5300, Austin, TX, 78712-1167 USA
These authors contributed equally to this work.
Search for more papers by this authorCorresponding Author
Prof. Michael J. Krische
University of Texas at Austin, Department of Chemistry, 105 E 24th St. A5300, Austin, TX, 78712-1167 USA
Search for more papers by this authorHongde Xiao
University of Texas at Austin, Department of Chemistry, 105 E 24th St. A5300, Austin, TX, 78712-1167 USA
These authors contributed equally to this work.
Search for more papers by this authorGang Wang
University of Texas at Austin, Department of Chemistry, 105 E 24th St. A5300, Austin, TX, 78712-1167 USA
These authors contributed equally to this work.
Search for more papers by this authorCorresponding Author
Prof. Michael J. Krische
University of Texas at Austin, Department of Chemistry, 105 E 24th St. A5300, Austin, TX, 78712-1167 USA
Search for more papers by this authorGraphical Abstract
Feedstocks to building blocks: Transfer hydrogenative coupling of styrene with primary alcohols using the precatalyst HClRu(CO)(PCy3)2 modified by AgOTf or HBF4 delivers branched or linear adducts from benzylic or aliphatic alcohols, respectively. Related 2-propanol mediated reductive couplings also are described.
Abstract
Transfer hydrogenative coupling of styrene with primary alcohols using the precatalyst HClRu(CO)(PCy3)2 modified by AgOTf or HBF4 delivers branched or linear adducts from benzylic or aliphatic alcohols, respectively. Related 2-propanol mediated reductive couplings also are described.
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