Paper-Based Electrical Respiration Sensor
Dr. Firat Güder
Department of Chemistry and Chemical Biology, Harvard University, 12 Oxford Street, Cambridge, MA, 02138 USA
Search for more papers by this authorDr. Alar Ainla
Department of Chemistry and Chemical Biology, Harvard University, 12 Oxford Street, Cambridge, MA, 02138 USA
Search for more papers by this authorJulia Redston
Department of Chemistry and Chemical Biology, Harvard University, 12 Oxford Street, Cambridge, MA, 02138 USA
Search for more papers by this authorProf. Bobak Mosadegh
Department of Chemistry and Chemical Biology, Harvard University, 12 Oxford Street, Cambridge, MA, 02138 USA
Wyss Institute for Biologically Inspired Engineering, Harvard University, 60 Oxford Street, Cambridge, MA, 02138 USA
Search for more papers by this authorDr. Ana Glavan
Department of Chemistry and Chemical Biology, Harvard University, 12 Oxford Street, Cambridge, MA, 02138 USA
Search for more papers by this authorT. J. Martin
Department of Chemistry and Chemical Biology, Harvard University, 12 Oxford Street, Cambridge, MA, 02138 USA
Search for more papers by this authorCorresponding Author
Prof. George M. Whitesides
Department of Chemistry and Chemical Biology, Harvard University, 12 Oxford Street, Cambridge, MA, 02138 USA
Wyss Institute for Biologically Inspired Engineering, Harvard University, 60 Oxford Street, Cambridge, MA, 02138 USA
Search for more papers by this authorDr. Firat Güder
Department of Chemistry and Chemical Biology, Harvard University, 12 Oxford Street, Cambridge, MA, 02138 USA
Search for more papers by this authorDr. Alar Ainla
Department of Chemistry and Chemical Biology, Harvard University, 12 Oxford Street, Cambridge, MA, 02138 USA
Search for more papers by this authorJulia Redston
Department of Chemistry and Chemical Biology, Harvard University, 12 Oxford Street, Cambridge, MA, 02138 USA
Search for more papers by this authorProf. Bobak Mosadegh
Department of Chemistry and Chemical Biology, Harvard University, 12 Oxford Street, Cambridge, MA, 02138 USA
Wyss Institute for Biologically Inspired Engineering, Harvard University, 60 Oxford Street, Cambridge, MA, 02138 USA
Search for more papers by this authorDr. Ana Glavan
Department of Chemistry and Chemical Biology, Harvard University, 12 Oxford Street, Cambridge, MA, 02138 USA
Search for more papers by this authorT. J. Martin
Department of Chemistry and Chemical Biology, Harvard University, 12 Oxford Street, Cambridge, MA, 02138 USA
Search for more papers by this authorCorresponding Author
Prof. George M. Whitesides
Department of Chemistry and Chemical Biology, Harvard University, 12 Oxford Street, Cambridge, MA, 02138 USA
Wyss Institute for Biologically Inspired Engineering, Harvard University, 60 Oxford Street, Cambridge, MA, 02138 USA
Search for more papers by this authorGraphical Abstract
Abstract
Current methods of monitoring breathing require cumbersome, inconvenient, and often expensive devices; this requirement sets practical limitations on the frequency and duration of measurements. This article describes a paper-based moisture sensor that uses the hygroscopic character of paper (i.e. the ability of paper to adsorb water reversibly from the surrounding environment) to measure patterns and rate of respiration by converting the changes in humidity caused by cycles of inhalation and exhalation to electrical signals. The changing level of humidity that occurs in a cycle causes a corresponding change in the ionic conductivity of the sensor, which can be measured electrically. By combining the paper sensor with conventional electronics, data concerning respiration can be transmitted to a nearby smartphone or tablet computer for post-processing, and subsequently to a cloud server. This means of sensing provides a new, practical method of recording and analyzing patterns of breathing.
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References
- 1
- 1aR. Parkes, Emerg. Nurse 2011, 19, 12–17;
- 1bZ. V. Edmonds, W. R. Mower, L. M. Lovato, R. Lomeli, Ann. Emerg. Med. 2002, 39, 233–237.
- 2M. A. Cretikos, R. Bellomo, K. Hillman, J. Chen, S. Finfer, A. Flabouris, Med. J. Aust. 2008, 188, 657.
- 3M. Woollard, I. Greaves, Emerg. Med. J. 2004, 21, 341–350.
- 4W. F. Ganong, K. E. Barrett, Review of Medical Physiology, Vol. 21, McGraw-Hill Medical, New York, 2005.
- 5J. F. Fieselmann, M. S. Hendryx, C. M. Helms, D. S. Wakefield, J. Gen. Intern. Med. 1993, 8, 354–360.
- 6
- 6aD. Noonan, Sci. Am. 2015, 312, 27–28;
- 6bP. E. Peppard, T. Young, J. H. Barnet, M. Palta, E. W. Hagen, K. M. Hla, Am. J. Epidemiol. 2013, 177, 1006–1014;
- 6cA. S. Gami, D. E. Howard, E. J. Olson, V. K. Somers, N. Engl. J. Med. 2005, 352, 1206–1214;
- 6dP. J. Strollo et. al., N. Engl. J. Med. 2014, 370, 139–149.
- 7
- 7aD. G. Carey, G. Pliego, R. Raymond, J. Exerc. Physiol. 2008, 11, 44–51;
- 7bD. G. Carey, L. A. Schwarz, G. J. Pliego, R. L. Raymond, J. Sports Sci. Med. 2005, 4, 482.
- 8R. B. George, M. A. Matthay, R. W. Light, R. A. Matthay, Chest Medicine: Essentials of Pulmonary and Critical Care Medicine, Lippincott Williams & Wilkins, Philadelphia, 2005.
- 9W. Karlen, H. Gan, M. Chiu, D. Dunsmuir, G. Zhou, G. A. Dumont, J. M. Ansermino, PLoS One 2014, 9, 99266.
- 10M. Folke, L. Cernerud, M. Ekström, B. Hök, Med. Biol. Eng. Comput. 2003, 41, 377–383.
- 11F. Q. Al-Khalidi, R. Saatchi, D. Burke, H. Elphick, S. Tan, Pediatr. Pulmonol. 2011, 46, 523–529.
- 12K. Storck, M. Karlsson, P. Ask, D. Loyd, IEEE Trans. Biomed. Eng. 1996, 43, 1187–1191.
- 13
- 13aR. G. Norman, M. M. Ahmed, J. A. Walsleben, D. M. Rapoport, Sleep 1997, 20, 1175–1184;
- 13bT. L. Lee-Chiong, Sleep: a comprehensive handbook, Wiley Online Library, 2006.
- 14
- 14aL. Autet, D. Frasca, M. Pinsard, A. Cancel, L. Rousseau, B. Debaene, O. Mimoz, Br. J. Anaesth. 2014, 113, 195–197;
- 14bY. Guechi, A. Pichot, D. Frasca, F. Rayeh-Pelardy, J.-Y. Lardeur, O. Mimoz, J. Clin. Monit. Comput. 2015, 1–6 (Available Online DOI: 10.1007/s10877-10015-19658-y);
- 14cH. Jin, L. Lee, L. Song, Y. Li, J. Peng, N. Zhong, H. Li, X. Zhang, J. Clin. Sleep Med. 2015, 11, 765–771.
- 15
- 15aN. Jaimchariyatam, R. A. Dweik, R. Kaw, L. S. Aboussouan, J. Clin. Sleep Med. 2013, 9, 209;
- 15bS. Yamamori, Y. Takasaki, M. Ozaki, H. Iseki, J. Clin. Monit. Comput. 2008, 22, 209–220;
- 15cM. L. Langhan, J. C. Kurtz, P. Schaeffer, A. G. Asnes, A. Riera, J. Crit. Care 2014, 29, 1035–1040;
- 15dC. Weihu, Y. Jingying, H. Demin, Z. Yuhuan, W. Jiangyong, Am. J. Otolaryngol. 2011, 32, 190–193.
- 16
- 16aD. Tobjörk, R. Österbacka, Adv. Mater. 2011, 23, 1935–1961;
- 16bR. E. Mark, J. Borch, Handbook of physical testing of paper, Vol. 1, CRC Press, Boca Raton, FL, 2001;
- 16cT. Unander, H.-E. Nilsson, IEEE Sens. J. 2009, 9, 922–928;
- 16dT. Unander, J. Sidén, H.-E. Nilsson, IEEE Sens. J. 2011, 11, 3009–3018.
- 17A. C. Glavan, D. C. Christodouleas, B. Mosadegh, H. D. Yu, B. S. Smith, J. Lessing, M. T. Fernández-Abedul, G. M. Whitesides, Anal. Chem. 2014, 86, 11999–12007.
- 18I. M. Hutten, Handbook of nonwoven media, Elsevier, Amsterdam, 2007.
- 19R. B. Roe, J. Am. Ceram. Soc. 1919, 2, 69–73.
- 20W. Dodds, L. Stutzman, B. Sollami, Industrial & Engineering Chemistry, Chemical & Engineering Data Series 1956, 1, 92–95; Engineering Chemistry, Chemical & Engineering Data Series 1956, 1, 92–95.
- 21S. W. Smith, The Scientist and Engineer's Guide to Digital Signal Processing, California Technical Publishing, San Diego, 1997.
- 22
- 22aF. Marvasti, A. Amini, F. Haddadi, M. Soltanolkotabi, B. H. Khalaj, A. Aldroubi, S. Sanei, J. A. Chambers, EURASIP J. Adv. Sig. Proc. 2012, 2012, 44;
- 22bD. J. Holland, L. F. Gladden, Angew. Chem. Int. Ed. 2014, 53, 13330–13340; Angew. Chem. 2014, 126, 13546–13557.
- 23Y. Y. Broza, P. Mochalski, V. Ruzsanyi, A. Amann, H. Haick, Angew. Chem. Int. Ed. 2015, 54, 11036–11048; Angew. Chem. 2015, 127, 11188–11201.