Volume 54, Issue 41 p. 11877
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Cover Picture: Self-Assembled DNA Nanoclews for the Efficient Delivery of CRISPR–Cas9 for Genome Editing (Angew. Chem. Int. Ed. 41/2015)

Wujin Sun

Wujin Sun

Joint Department of Biomedical Engineering, University of North Carolina at Chapel Hill and North Carolina State University, Raleigh, NC 27695 (USA)

Division of Molecular Pharmaceutics and Center for Nanotechnology in Drug Delivery, Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 (USA)

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Wenyan Ji

Wenyan Ji

Joint Department of Biomedical Engineering, University of North Carolina at Chapel Hill and North Carolina State University, Raleigh, NC 27695 (USA)

Division of Molecular Pharmaceutics and Center for Nanotechnology in Drug Delivery, Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 (USA)

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Jordan M. Hall

Jordan M. Hall

Department of Chemical and Biomolecular Engineering, North Carolina State University, Raleigh, NC 27695-7905 (USA)

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Quanyin Hu

Quanyin Hu

Joint Department of Biomedical Engineering, University of North Carolina at Chapel Hill and North Carolina State University, Raleigh, NC 27695 (USA)

Division of Molecular Pharmaceutics and Center for Nanotechnology in Drug Delivery, Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 (USA)

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Dr. Chao Wang

Dr. Chao Wang

Joint Department of Biomedical Engineering, University of North Carolina at Chapel Hill and North Carolina State University, Raleigh, NC 27695 (USA)

Division of Molecular Pharmaceutics and Center for Nanotechnology in Drug Delivery, Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 (USA)

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Prof. Dr. Chase L. Beisel

Corresponding Author

Prof. Dr. Chase L. Beisel

Department of Chemical and Biomolecular Engineering, North Carolina State University, Raleigh, NC 27695-7905 (USA)

Chase L. Beisel, Department of Chemical and Biomolecular Engineering, North Carolina State University, Raleigh, NC 27695-7905 (USA)

Zhen Gu, Joint Department of Biomedical Engineering, University of North Carolina at Chapel Hill and North Carolina State University, Raleigh, NC 27695 (USA)

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Prof. Dr. Zhen Gu

Corresponding Author

Prof. Dr. Zhen Gu

Joint Department of Biomedical Engineering, University of North Carolina at Chapel Hill and North Carolina State University, Raleigh, NC 27695 (USA)

Division of Molecular Pharmaceutics and Center for Nanotechnology in Drug Delivery, Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 (USA)

Department of Medicine, University of North Carolina School of Medicine, Chapel Hill, NC 27599 (USA)

Chase L. Beisel, Department of Chemical and Biomolecular Engineering, North Carolina State University, Raleigh, NC 27695-7905 (USA)

Zhen Gu, Joint Department of Biomedical Engineering, University of North Carolina at Chapel Hill and North Carolina State University, Raleigh, NC 27695 (USA)

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First published: 21 September 2015
Citations: 2

Graphical Abstract

A biologically inspired carrier for the delivery of CRISPR–Cas9 that is based on yarn-like DNA nanoparticles, so-called DNA nanoclews, is described by Z. Gu, C. L. Beisel, and co-workers in their Communication on page 12029 ff. DNA nanoclews (the flying saucers), partially complementary to the single guide RNA (sgRNA), were efficiently loaded with Cas9/sgRNA complexes (the missiles) and delivered the complexes into human cells for genome editing.

Description unavailable

A biologically inspired carrier for the delivery of CRISPR–Cas9 that is based on yarn-like DNA nanoparticles, so-called DNA nanoclews, is described by Z. Gu, C. L. Beisel, and co-workers in their Communication on page 12029 ff. DNA nanoclews (the flying saucers), partially complementary to the single guide RNA (sgRNA), were efficiently loaded with Cas9/sgRNA complexes (the missiles) and delivered the complexes into human cells for genome editing.

Propylene Epoxidation Catalysts

Cu+ active sites on a Cu2O surface are stabilized with TiOx. J. G. Chen et al. show in their Communication on page 11946 ff. that the resulting mixed oxide helps form an oxametallacycle intermediate with propylene giving higher selectivity for propylene epoxidation.

Main Group Chemistry

In their Communication on page 12034 ff., F. M. Bickelhaupt, M. G. Goesten et al. report that the bonding in six-coordinate Group 13 complexes is best described in terms of 7-center-12-electron bonds.

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