Disruption of the Dynamics of Microtubules and Selective Inhibition of Glioblastoma Cells by Nanofibers of Small Hydrophobic Molecules†
Yi Kuang
Department of Chemistry, Brandeis University, 415 South Street, Waltham, MA 02453 (USA) http://people.brandeis.edu/∼bxu/
Search for more papers by this authorCorresponding Author
Prof. Bing Xu
Department of Chemistry, Brandeis University, 415 South Street, Waltham, MA 02453 (USA) http://people.brandeis.edu/∼bxu/
Department of Chemistry, Brandeis University, 415 South Street, Waltham, MA 02453 (USA) http://people.brandeis.edu/∼bxu/Search for more papers by this authorYi Kuang
Department of Chemistry, Brandeis University, 415 South Street, Waltham, MA 02453 (USA) http://people.brandeis.edu/∼bxu/
Search for more papers by this authorCorresponding Author
Prof. Bing Xu
Department of Chemistry, Brandeis University, 415 South Street, Waltham, MA 02453 (USA) http://people.brandeis.edu/∼bxu/
Department of Chemistry, Brandeis University, 415 South Street, Waltham, MA 02453 (USA) http://people.brandeis.edu/∼bxu/Search for more papers by this authorThis research was partially supported by the NIH (R01CA142746) and startup funds from Brandeis University. We acknowledge the help of the EM facility at Brandeis University. B.X. thanks Prof. N. Grigorieff for advice on TEM.
Graphical Abstract
Ganging up against the bad guys: Nanofibers of 1 efficiently inhibited the growth of glioblastoma cells but exhibited little acute toxicity toward a neuronal cell line. The selective cytotoxicity probably stems from the Warburg effect of cancer cells and the existence of microtubule-stabilizing proteins in neurons. Supramolecular nanofibers that can interrupt the self-organization of proteins may have potential as nanomedicines for the treatment of cancer.
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