Acceptorless Dehydrogenation of Nitrogen Heterocycles with a Versatile Iridium Catalyst†
Jianjun Wu
Department of Chemistry, University of Liverpool, Liverpool L69 7ZD (UK)
These authors contributed equally to this work.
Search for more papers by this authorDinesh Talwar
Department of Chemistry, University of Liverpool, Liverpool L69 7ZD (UK)
These authors contributed equally to this work.
Search for more papers by this authorSteven Johnston
Department of Chemistry, University of Liverpool, Liverpool L69 7ZD (UK)
Search for more papers by this authorProf. Ming Yan
Institute of Drug Synthesis and Pharmaceutical Process, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006 (China)
Search for more papers by this authorCorresponding Author
Prof. Jianliang Xiao
Department of Chemistry, University of Liverpool, Liverpool L69 7ZD (UK)
Department of Chemistry, University of Liverpool, Liverpool L69 7ZD (UK)Search for more papers by this authorJianjun Wu
Department of Chemistry, University of Liverpool, Liverpool L69 7ZD (UK)
These authors contributed equally to this work.
Search for more papers by this authorDinesh Talwar
Department of Chemistry, University of Liverpool, Liverpool L69 7ZD (UK)
These authors contributed equally to this work.
Search for more papers by this authorSteven Johnston
Department of Chemistry, University of Liverpool, Liverpool L69 7ZD (UK)
Search for more papers by this authorProf. Ming Yan
Institute of Drug Synthesis and Pharmaceutical Process, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006 (China)
Search for more papers by this authorCorresponding Author
Prof. Jianliang Xiao
Department of Chemistry, University of Liverpool, Liverpool L69 7ZD (UK)
Department of Chemistry, University of Liverpool, Liverpool L69 7ZD (UK)Search for more papers by this authorWe thank the EPSRC and the University of Liverpool for a DTA studentship, Dr. Weijun Tang, Yi Zhang, and Dr. Jonathan H. Barnard for assistance and the EPSRC NMSSC at Swansea University for mass analysis.
Graphical Abstract
Gas up: A cyclometalated iridium complex is found to catalyze the dehydrogenation of various benzofused N-heterocycles, thus releasing H2. Driven by as low as 0.1 mol % catalyst, the reaction affords quinolines, indoles, quinoxalines, isoquinolines, and β-carbolines in high yields.
Supporting Information
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