Catalyzed Dehydrogenative Coupling of Primary Alcohols with Water, Methanol, or Amines†
Theo Zweifel Dipl.-Chem.
Department of Chemistry and Applied Biology, ETH-Hönggerberg, CH-8093 Zurich, Switzerland
Search for more papers by this authorJean-Valère Naubron Dr.
Department of Chemistry and Applied Biology, ETH-Hönggerberg, CH-8093 Zurich, Switzerland
Search for more papers by this authorHansjörg Grützmacher Prof. Dr.
Department of Chemistry and Applied Biology, ETH-Hönggerberg, CH-8093 Zurich, Switzerland
Search for more papers by this authorTheo Zweifel Dipl.-Chem.
Department of Chemistry and Applied Biology, ETH-Hönggerberg, CH-8093 Zurich, Switzerland
Search for more papers by this authorJean-Valère Naubron Dr.
Department of Chemistry and Applied Biology, ETH-Hönggerberg, CH-8093 Zurich, Switzerland
Search for more papers by this authorHansjörg Grützmacher Prof. Dr.
Department of Chemistry and Applied Biology, ETH-Hönggerberg, CH-8093 Zurich, Switzerland
Search for more papers by this authorThis work was supported by the Swiss National Science Foundation (SNF) and the ETH Zurich
Graphical Abstract
A working partnership: Metal–ligand cooperativity is responsible for the high activity of the rhodium amido complex 1 in the dehydrogenative coupling of primary alcohols with water, methanol, or amines, including ammonia (see scheme), to give carboxylic acids, methyl carboxylates, or amides, respectively. The catalysis proceeds under mild reaction conditions in the presence of a recyclable hydrogen acceptor A. The multistep mechanism was elucidated by computational methods.
Supporting Information
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