Highly Active Chiral Ruthenium Catalysts for Asymmetric Cross- and Ring-Opening Cross-Metathesis†
Jacob M. Berlin
Arnold and Mabel Beckman Laboratories of Chemical Synthesis, California Institute of Technology, Division of Chemistry and Chemical Engineering, Mail Code 164-30, Pasadena, CA 91125, USA, Fax: (+1) 626-564-9297
Search for more papers by this authorSteven D. Goldberg Dr.
Arnold and Mabel Beckman Laboratories of Chemical Synthesis, California Institute of Technology, Division of Chemistry and Chemical Engineering, Mail Code 164-30, Pasadena, CA 91125, USA, Fax: (+1) 626-564-9297
Search for more papers by this authorRobert H. Grubbs Prof.
Arnold and Mabel Beckman Laboratories of Chemical Synthesis, California Institute of Technology, Division of Chemistry and Chemical Engineering, Mail Code 164-30, Pasadena, CA 91125, USA, Fax: (+1) 626-564-9297
Search for more papers by this authorJacob M. Berlin
Arnold and Mabel Beckman Laboratories of Chemical Synthesis, California Institute of Technology, Division of Chemistry and Chemical Engineering, Mail Code 164-30, Pasadena, CA 91125, USA, Fax: (+1) 626-564-9297
Search for more papers by this authorSteven D. Goldberg Dr.
Arnold and Mabel Beckman Laboratories of Chemical Synthesis, California Institute of Technology, Division of Chemistry and Chemical Engineering, Mail Code 164-30, Pasadena, CA 91125, USA, Fax: (+1) 626-564-9297
Search for more papers by this authorRobert H. Grubbs Prof.
Arnold and Mabel Beckman Laboratories of Chemical Synthesis, California Institute of Technology, Division of Chemistry and Chemical Engineering, Mail Code 164-30, Pasadena, CA 91125, USA, Fax: (+1) 626-564-9297
Search for more papers by this authorWe gratefully acknowledge Prof. F. D. Toste for early experimental work.
Graphical Abstract
Metathesis takes sides: The scope of asymmetric metathesis has been expanded with the use of chiral ruthenium catalysts for asymmetric ring-opening cross-metathesis and for the first example of an asymmetric cross-metathesis (see scheme, TIPS=triisopropylsilyl). Information about the mechanism of asymmetric ring-opening cross-metathesis should allow the development of more selective catalysts.
Supporting Information
Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2002/2006/z602469_s.pdf or from the author.
Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
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