Switch Peptides In Statu Nascendi: Induction of Conformational Transitions Relevant to Degenerative Diseases†
Manfred Mutter Prof.
Institute of Chemical Sciences and Engineering (ISIC), Swiss Federal Institute of Technology, EPFL-BCH, 1015 Lausanne, Switzerland, Fax: (+41) 21-693-9415
Search for more papers by this authorArunan Chandravarkar Dr.
Institute of Chemical Sciences and Engineering (ISIC), Swiss Federal Institute of Technology, EPFL-BCH, 1015 Lausanne, Switzerland, Fax: (+41) 21-693-9415
Search for more papers by this authorChristine Boyat Dr.
Institute of Chemical Sciences and Engineering (ISIC), Swiss Federal Institute of Technology, EPFL-BCH, 1015 Lausanne, Switzerland, Fax: (+41) 21-693-9415
Search for more papers by this authorJohn Lopez Dr.
Institute of Chemical Sciences and Engineering (ISIC), Swiss Federal Institute of Technology, EPFL-BCH, 1015 Lausanne, Switzerland, Fax: (+41) 21-693-9415
Search for more papers by this authorSonia Dos Santos Dipl.-Chem.
Institute of Chemical Sciences and Engineering (ISIC), Swiss Federal Institute of Technology, EPFL-BCH, 1015 Lausanne, Switzerland, Fax: (+41) 21-693-9415
Search for more papers by this authorBhubaneswar Mandal Dipl.-Chem.
Institute of Chemical Sciences and Engineering (ISIC), Swiss Federal Institute of Technology, EPFL-BCH, 1015 Lausanne, Switzerland, Fax: (+41) 21-693-9415
Search for more papers by this authorRichard Mimna Dipl.-Chem.
Institute of Chemical Sciences and Engineering (ISIC), Swiss Federal Institute of Technology, EPFL-BCH, 1015 Lausanne, Switzerland, Fax: (+41) 21-693-9415
Search for more papers by this authorKarine Murat Dipl.-Chem.
Institute of Chemical Sciences and Engineering (ISIC), Swiss Federal Institute of Technology, EPFL-BCH, 1015 Lausanne, Switzerland, Fax: (+41) 21-693-9415
Search for more papers by this authorLuc Patiny Dr.
Institute of Chemical Sciences and Engineering (ISIC), Swiss Federal Institute of Technology, EPFL-BCH, 1015 Lausanne, Switzerland, Fax: (+41) 21-693-9415
Search for more papers by this authorLydiane Saucède Dipl.-Chem.
Institute of Chemical Sciences and Engineering (ISIC), Swiss Federal Institute of Technology, EPFL-BCH, 1015 Lausanne, Switzerland, Fax: (+41) 21-693-9415
Search for more papers by this authorGabriele Tuchscherer Dr.
Institute of Chemical Sciences and Engineering (ISIC), Swiss Federal Institute of Technology, EPFL-BCH, 1015 Lausanne, Switzerland, Fax: (+41) 21-693-9415
Search for more papers by this authorManfred Mutter Prof.
Institute of Chemical Sciences and Engineering (ISIC), Swiss Federal Institute of Technology, EPFL-BCH, 1015 Lausanne, Switzerland, Fax: (+41) 21-693-9415
Search for more papers by this authorArunan Chandravarkar Dr.
Institute of Chemical Sciences and Engineering (ISIC), Swiss Federal Institute of Technology, EPFL-BCH, 1015 Lausanne, Switzerland, Fax: (+41) 21-693-9415
Search for more papers by this authorChristine Boyat Dr.
Institute of Chemical Sciences and Engineering (ISIC), Swiss Federal Institute of Technology, EPFL-BCH, 1015 Lausanne, Switzerland, Fax: (+41) 21-693-9415
Search for more papers by this authorJohn Lopez Dr.
Institute of Chemical Sciences and Engineering (ISIC), Swiss Federal Institute of Technology, EPFL-BCH, 1015 Lausanne, Switzerland, Fax: (+41) 21-693-9415
Search for more papers by this authorSonia Dos Santos Dipl.-Chem.
Institute of Chemical Sciences and Engineering (ISIC), Swiss Federal Institute of Technology, EPFL-BCH, 1015 Lausanne, Switzerland, Fax: (+41) 21-693-9415
Search for more papers by this authorBhubaneswar Mandal Dipl.-Chem.
Institute of Chemical Sciences and Engineering (ISIC), Swiss Federal Institute of Technology, EPFL-BCH, 1015 Lausanne, Switzerland, Fax: (+41) 21-693-9415
Search for more papers by this authorRichard Mimna Dipl.-Chem.
Institute of Chemical Sciences and Engineering (ISIC), Swiss Federal Institute of Technology, EPFL-BCH, 1015 Lausanne, Switzerland, Fax: (+41) 21-693-9415
Search for more papers by this authorKarine Murat Dipl.-Chem.
Institute of Chemical Sciences and Engineering (ISIC), Swiss Federal Institute of Technology, EPFL-BCH, 1015 Lausanne, Switzerland, Fax: (+41) 21-693-9415
Search for more papers by this authorLuc Patiny Dr.
Institute of Chemical Sciences and Engineering (ISIC), Swiss Federal Institute of Technology, EPFL-BCH, 1015 Lausanne, Switzerland, Fax: (+41) 21-693-9415
Search for more papers by this authorLydiane Saucède Dipl.-Chem.
Institute of Chemical Sciences and Engineering (ISIC), Swiss Federal Institute of Technology, EPFL-BCH, 1015 Lausanne, Switzerland, Fax: (+41) 21-693-9415
Search for more papers by this authorGabriele Tuchscherer Dr.
Institute of Chemical Sciences and Engineering (ISIC), Swiss Federal Institute of Technology, EPFL-BCH, 1015 Lausanne, Switzerland, Fax: (+41) 21-693-9415
Search for more papers by this authorThis work was supported by the Swiss National Science Foundation. The Ncap peptidomimetic was a generous gift from Prof. Klaus Müller, Hoffman-La Roche, Basel, Switzerland.
Graphical Abstract
A novel concept for triggering conformational transitions, and thus changes in structure and function, in peptides with a switching element S provides intriguing perspectives for studying molecular processes (see scheme) that play a key role, for example, in early events of Alzheimer's disease.
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