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Solid Phase Synthesis (Nobel Lecture)†
Prof. Robert Bruce Merrifield,
Corresponding Author
Prof. Robert Bruce Merrifield
The Rockefeller University, 1230 York Avenue, New York, NY 10021-6399 (USA)
The Rockefeller University, 1230 York Avenue, New York, NY 10021-6399 (USA)Search for more papers by this authorProf. Robert Bruce Merrifield,
Corresponding Author
Prof. Robert Bruce Merrifield
The Rockefeller University, 1230 York Avenue, New York, NY 10021-6399 (USA)
The Rockefeller University, 1230 York Avenue, New York, NY 10021-6399 (USA)Search for more papers by this author†
Copyright © The Noble Foundation 1985.—We thank the Nobel Foundation, Stockholm, for permission to print this article.
Abstract
A solid phase as “protecting group” in peptide synthesis—this was the original idea of Bruce Merrifield, who received the 1984 Nobel Prize for Chemistry. In his lecture, he describes the development of the Merrifield synthesis. In principle, all difunctional educts that may be selectively protected at one end and activated at the other can undergo reactions on solid supports.
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