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Chemistry and Function of Human Plasma Proteins†
Prof. Dr. Hans-Gerhard Schwick,
Heinz Haupt,
Prof. Dr. Hans-Gerhard Schwick
Behringwerke AG, D-3550 Marburg/Lahn (Germany)
Search for more papers by this authorCorresponding Author
Heinz Haupt
Behringwerke AG, D-3550 Marburg/Lahn (Germany)
Behringwerke AG, D-3550 Marburg/Lahn (Germany)Search for more papers by this authorProf. Dr. Hans-Gerhard Schwick,
Heinz Haupt,
Prof. Dr. Hans-Gerhard Schwick
Behringwerke AG, D-3550 Marburg/Lahn (Germany)
Search for more papers by this authorCorresponding Author
Heinz Haupt
Behringwerke AG, D-3550 Marburg/Lahn (Germany)
Behringwerke AG, D-3550 Marburg/Lahn (Germany)Search for more papers by this author†
Dedicated to Professor Rolf Sammet on the occasion of his 60th birthday
Abstract
Human blood plasma contains a large number of proteins. New analytical and preparative techniques have so far permitted the isolation of more than one hundred such proteins; about ninety percent of these were first characterized in the last 30 years. The plasma proteins include components of the clotting and complement systems as well as proteinase inhibitors, immunoglobulins, lipoproteins, and carrier proteins. The biological function of some of the plasma proteins is not yet known. Deficiency of one or more plasma proteins usually causes serious health disorders, the best known example being hemophilia. Several biologically active proteins can be gained from blood plasma; these proteins—for example the blood clotting factors—are of great prophylactic and therapeutic importance and allow a better exploitation of the valuable plasma than can be obtained by means of transfusion.
Abstract
Components of the blood clotting system, immunoglobulins, lipoproteins, and numerous other proteins—numbering over 100—have been isolated from blood plasma by new techniques. Some of the biologically active proteins obtainable in this way possess considerable prophylactic and therapeutic potential. In fact, blood plasma would appear too valuable for mere transfusion.
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