Volume 132, Issue 26 pp. 10622-10626
Forschungsartikel

Droplet Precise Self-Splitting on Patterned Adhesive Surfaces for Simultaneous Multidetection

Dr. Huizeng Li

Dr. Huizeng Li

Key Laboratory of Green Printing, Institute of Chemistry, Chinese Academy of Sciences (ICCAS), Beijing Engineering Research Center of Nanomaterials for Green Printing Technology, National Laboratory for Molecular Sciences (BNLMS), Beijing, 100190 P. R. China

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Wei Fang

Wei Fang

AML, CNMM, and Department of Engineering Mechanics, and State Key Laboratory of Tribology, Tsinghua University, Beijing, 100084 P. R. China

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Zhipeng Zhao

Zhipeng Zhao

Key Laboratory of Green Printing, Institute of Chemistry, Chinese Academy of Sciences (ICCAS), Beijing Engineering Research Center of Nanomaterials for Green Printing Technology, National Laboratory for Molecular Sciences (BNLMS), Beijing, 100190 P. R. China

University of Chinese Academy of Sciences, Beijing, 100049 P. R. China

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An Li

An Li

Key Laboratory of Green Printing, Institute of Chemistry, Chinese Academy of Sciences (ICCAS), Beijing Engineering Research Center of Nanomaterials for Green Printing Technology, National Laboratory for Molecular Sciences (BNLMS), Beijing, 100190 P. R. China

University of Chinese Academy of Sciences, Beijing, 100049 P. R. China

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Dr. Zheng Li

Dr. Zheng Li

Key Laboratory of Green Printing, Institute of Chemistry, Chinese Academy of Sciences (ICCAS), Beijing Engineering Research Center of Nanomaterials for Green Printing Technology, National Laboratory for Molecular Sciences (BNLMS), Beijing, 100190 P. R. China

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Prof. Mingzhu Li

Corresponding Author

Prof. Mingzhu Li

Key Laboratory of Green Printing, Institute of Chemistry, Chinese Academy of Sciences (ICCAS), Beijing Engineering Research Center of Nanomaterials for Green Printing Technology, National Laboratory for Molecular Sciences (BNLMS), Beijing, 100190 P. R. China

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Prof. Qunyang Li

Corresponding Author

Prof. Qunyang Li

AML, CNMM, and Department of Engineering Mechanics, and State Key Laboratory of Tribology, Tsinghua University, Beijing, 100084 P. R. China

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Prof. Xiqiao Feng

Prof. Xiqiao Feng

AML, CNMM, and Department of Engineering Mechanics, and State Key Laboratory of Tribology, Tsinghua University, Beijing, 100084 P. R. China

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Prof. Yanlin Song

Corresponding Author

Prof. Yanlin Song

Key Laboratory of Green Printing, Institute of Chemistry, Chinese Academy of Sciences (ICCAS), Beijing Engineering Research Center of Nanomaterials for Green Printing Technology, National Laboratory for Molecular Sciences (BNLMS), Beijing, 100190 P. R. China

University of Chinese Academy of Sciences, Beijing, 100049 P. R. China

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First published: 09 April 2020

Dedicated to Professor Youqi Tang on the occasion of his 100th birthday

Abstract

Precise separation and localization of microdroplets are fundamental for various fields, such as high-throughput screening, combinatorial chemistry, and the recognition of complex analytes. We have developed a droplet self-splitting strategy to divide an impacting droplet into predictable microdroplets and deposit them at preset spots for simultaneous multidetection. No matter exchange was observed between these microdroplets, so they could be manipulated independently. Droplet self-splitting was attributed to anisotropic liquid recoiling on the patterned adhesive surface, as influenced by the droplet Weber number and the width of the low-adhesive stripe. A quantitative criterion was also developed to judge the droplet self-splitting capability. The precise separation and distribution of microdroplets enabled simultaneous arrayed reactions and multiple analyte detection using one droplet of sample.

Conflict of interest

The authors declare no conflict of interest.

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