Volume 132, Issue 7 p. 2936

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Rücktitelbild: Theranostic Layer-by-Layer Nanoparticles for Simultaneous Tumor Detection and Gene Silencing (Angew. Chem. 7/2020)

Dr. Natalie Boehnke,

Dr. Natalie Boehnke

Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, 02139 USA

These authors contributed equally to this work.

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Dr. Santiago Correa,

Dr. Santiago Correa

Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, 02139 USA

Department of Bioengineering, Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, 02139 USA

Current address: Materials Science and Engineering, Stanford University, 496 Lomita Mall, Stanford, CA, 94305 USA

These authors contributed equally to this work.

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Dr. Liangliang Hao,

Dr. Liangliang Hao

Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, 02139 USA

Institute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, MA, 02139 USA

These authors contributed equally to this work.

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Dr. Wade Wang,

Dr. Wade Wang

Department of Chemistry, Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, 02139 USA

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Dr. Joelle P. Straehla,

Dr. Joelle P. Straehla

Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, 02139 USA

Department of Pediatric Oncology, Dana-Farber/Boston Children's Cancer and Blood Disorders Center, Boston, MA, 02115 USA

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Prof. Sangeeta N. Bhatia,

Prof. Sangeeta N. Bhatia

Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, 02139 USA

Institute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, MA, 02139 USA

Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, 02115 USA

Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA, 02139 USA

Howard Hughes Medical Institute, Cambridge, MA, 02139 USA

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Prof. Paula T. Hammond,

Corresponding Author

Prof. Paula T. Hammond

[email protected]

orcid.org/0000-0002-9835-192X

Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, 02139 USA

Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA, 02139 USA

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Dr. Natalie Boehnke,

Dr. Natalie Boehnke

Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, 02139 USA

These authors contributed equally to this work.

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Dr. Santiago Correa,

Dr. Santiago Correa

Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, 02139 USA

Department of Bioengineering, Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, 02139 USA

Current address: Materials Science and Engineering, Stanford University, 496 Lomita Mall, Stanford, CA, 94305 USA

These authors contributed equally to this work.

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Dr. Liangliang Hao,

Dr. Liangliang Hao

Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, 02139 USA

Institute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, MA, 02139 USA

These authors contributed equally to this work.

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Dr. Wade Wang,

Dr. Wade Wang

Department of Chemistry, Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, 02139 USA

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Dr. Joelle P. Straehla,

Dr. Joelle P. Straehla

Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, 02139 USA

Department of Pediatric Oncology, Dana-Farber/Boston Children's Cancer and Blood Disorders Center, Boston, MA, 02115 USA

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Prof. Sangeeta N. Bhatia,

Prof. Sangeeta N. Bhatia

Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, 02139 USA

Institute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, MA, 02139 USA

Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, 02115 USA

Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA, 02139 USA

Howard Hughes Medical Institute, Cambridge, MA, 02139 USA

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Prof. Paula T. Hammond,

Corresponding Author

Prof. Paula T. Hammond

[email protected]

orcid.org/0000-0002-9835-192X

Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, 02139 USA

Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA, 02139 USA

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First published: 20 January 2020

https://doi.org/10.1002/ange.201916374

Citations: 1

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Graphical Abstract

Geschichtete, mit Protease-responsiven Peptid-Biomarkern funktionalisierte und mit siRNA beladene Nanopartikel ermöglichen die nicht-invasive Harn-Diagnostik in Mausmodellen drei verschiedener Krebsarten mit gleichzeitiger Genstummschaltung in angrenzenden und metastatischen Mausmodellen von Eierstockkrebs. P. T. Hammond et al. beschreiben in ihrem Forschungsartikel auf S. 2798 eine modulare Nanotheranostik-Plattform, die Tumore sowohl stören als auch charakterisieren kann, was die gleichzeitige Behandlung und Überwachung der Krankheit ermöglicht.