Volume 127, Issue 43 p. 13016
Titelbild
Free Access

Rücktitelbild: Discovery of a Single Monooxygenase that Catalyzes Carbamate Formation and Ring Contraction in the Biosynthesis of the Legonmycins (Angew. Chem. 43/2015)

Sheng Huang

Sheng Huang

Key Laboratory of Combinatory Biosynthesis and Drug Discovery (Ministry of Education), School of Pharmaceutical Sciences, Wuhan University, 185 East Lake Road, Wuhan 430071 (P.R. China)

These authors contributed equally to this work.

Search for more papers by this author
Dr. Jioji Tabudravu

Dr. Jioji Tabudravu

Department of Chemistry, University of Aberdeen, Aberdeen (UK)

These authors contributed equally to this work.

Search for more papers by this author
Somayah S. Elsayed

Somayah S. Elsayed

Department of Chemistry, University of Aberdeen, Aberdeen (UK)

These authors contributed equally to this work.

Search for more papers by this author
Jeanne Travert

Jeanne Travert

Department of Chemistry, University of Aberdeen, Aberdeen (UK)

Search for more papers by this author
Doe Peace

Doe Peace

Department of Chemistry, University of Aberdeen, Aberdeen (UK)

Search for more papers by this author
Ming Him Tong

Ming Him Tong

Department of Chemistry, University of Aberdeen, Aberdeen (UK)

Search for more papers by this author
Dr. Kwaku Kyeremeh

Dr. Kwaku Kyeremeh

Department of Chemistry, University of Ghana, P.O. Box LG56, Legon-Accra (Ghana)

Search for more papers by this author
Dr. Sharon M. Kelly

Dr. Sharon M. Kelly

Institute of Molecular, Cell and Systems Biology, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, G12 8QQ (UK)

Search for more papers by this author
Dr. Laurent Trembleau

Dr. Laurent Trembleau

Department of Chemistry, University of Aberdeen, Aberdeen (UK)

Search for more papers by this author
Dr. Rainer Ebel

Dr. Rainer Ebel

Department of Chemistry, University of Aberdeen, Aberdeen (UK)

Search for more papers by this author
Prof. Dr. Marcel Jaspars

Prof. Dr. Marcel Jaspars

Department of Chemistry, University of Aberdeen, Aberdeen (UK)

Search for more papers by this author
Dr. Yi Yu

Corresponding Author

Dr. Yi Yu

Key Laboratory of Combinatory Biosynthesis and Drug Discovery (Ministry of Education), School of Pharmaceutical Sciences, Wuhan University, 185 East Lake Road, Wuhan 430071 (P.R. China)

Yi Yu, Key Laboratory of Combinatory Biosynthesis and Drug Discovery (Ministry of Education), School of Pharmaceutical Sciences, Wuhan University, 185 East Lake Road, Wuhan 430071 (P.R. China)

Hai Deng, Department of Chemistry, University of Aberdeen, Aberdeen (UK)

Search for more papers by this author
Dr. Hai Deng

Corresponding Author

Dr. Hai Deng

Department of Chemistry, University of Aberdeen, Aberdeen (UK)

Yi Yu, Key Laboratory of Combinatory Biosynthesis and Drug Discovery (Ministry of Education), School of Pharmaceutical Sciences, Wuhan University, 185 East Lake Road, Wuhan 430071 (P.R. China)

Hai Deng, Department of Chemistry, University of Aberdeen, Aberdeen (UK)

Search for more papers by this author
First published: 17 July 2015

Graphical Abstract

Das multifunktionelle Baeyer-Villiger-Enzym …︁…︁ LgnC katalysiert die Umsetzung von Indolizidinen zu Pyrrolizidinen durch Carbamat-Bildung, Hydrolyse, decarboxylierende Ringkontraktion und Hydroxylierung. In ihrer Zuschrift auf S. 12888 ff. zeigen H. Deng, Y. Yu et al., dass dies die entscheidenden Schritte bei der Biosynthese der Legonmycine sind – neuartige bakterielle Pyrrolizidin-Alkaloide, benannt nach der ghanaischen Stadt Legon.

Description unavailable

    The full text of this article hosted at iucr.org is unavailable due to technical difficulties.