Lab-on-a-Chip Reactor Imaging with Unprecedented Chemical Resolution by Hadamard-Encoded Remote Detection NMR†
Corresponding Author
Dr. Ville-Veikko Telkki
NMR Research Group, Department of Physics, University of Oulu, P.O. Box 3000, 90014 Oulu (Finland) http://cc.oulu.fi/∼nmrwww/
NMR Research Group, Department of Physics, University of Oulu, P.O. Box 3000, 90014 Oulu (Finland) http://cc.oulu.fi/∼nmrwww/Search for more papers by this authorDr. Vladimir V. Zhivonitko
Laboratory of Magnetic Resonance Microimaging, International Tomography Center SB RAS, 3A Institutskaya St., Novosibirsk 630090 (Russia)
Novosibirsk State University, Pirogova St. 2, Novosibirsk 630090 (Russia)
Search for more papers by this authorM. Sc. Anne Selent
NMR Research Group, Department of Physics, University of Oulu, P.O. Box 3000, 90014 Oulu (Finland) http://cc.oulu.fi/∼nmrwww/
Search for more papers by this authorDr. Gianmario Scotti
Department of Materials Science and Engineering, Aalto University, P.O. Box 16200, 00076 Aalto (Finland)
Search for more papers by this authorM. Sc. Jarmo Leppäniemi
Department of Materials Science and Engineering, Aalto University, P.O. Box 16200, 00076 Aalto (Finland)
Search for more papers by this authorProf. Sami Franssila
Department of Materials Science and Engineering, Aalto University, P.O. Box 16200, 00076 Aalto (Finland)
Search for more papers by this authorProf. Igor V. Koptyug
Laboratory of Magnetic Resonance Microimaging, International Tomography Center SB RAS, 3A Institutskaya St., Novosibirsk 630090 (Russia)
Novosibirsk State University, Pirogova St. 2, Novosibirsk 630090 (Russia)
Search for more papers by this authorCorresponding Author
Dr. Ville-Veikko Telkki
NMR Research Group, Department of Physics, University of Oulu, P.O. Box 3000, 90014 Oulu (Finland) http://cc.oulu.fi/∼nmrwww/
NMR Research Group, Department of Physics, University of Oulu, P.O. Box 3000, 90014 Oulu (Finland) http://cc.oulu.fi/∼nmrwww/Search for more papers by this authorDr. Vladimir V. Zhivonitko
Laboratory of Magnetic Resonance Microimaging, International Tomography Center SB RAS, 3A Institutskaya St., Novosibirsk 630090 (Russia)
Novosibirsk State University, Pirogova St. 2, Novosibirsk 630090 (Russia)
Search for more papers by this authorM. Sc. Anne Selent
NMR Research Group, Department of Physics, University of Oulu, P.O. Box 3000, 90014 Oulu (Finland) http://cc.oulu.fi/∼nmrwww/
Search for more papers by this authorDr. Gianmario Scotti
Department of Materials Science and Engineering, Aalto University, P.O. Box 16200, 00076 Aalto (Finland)
Search for more papers by this authorM. Sc. Jarmo Leppäniemi
Department of Materials Science and Engineering, Aalto University, P.O. Box 16200, 00076 Aalto (Finland)
Search for more papers by this authorProf. Sami Franssila
Department of Materials Science and Engineering, Aalto University, P.O. Box 16200, 00076 Aalto (Finland)
Search for more papers by this authorProf. Igor V. Koptyug
Laboratory of Magnetic Resonance Microimaging, International Tomography Center SB RAS, 3A Institutskaya St., Novosibirsk 630090 (Russia)
Novosibirsk State University, Pirogova St. 2, Novosibirsk 630090 (Russia)
Search for more papers by this authorThe financial support by the grants from the Academy of Finland (no 270195), RFBR (12-03-00403-a), the Council on Grants of the President of the Russian Federation (MK-1329.2014.3), and by the Ministry of Education and Science of the Russian Federation is gratefully acknowledged. A.S. thanks the Graduate School of Computational Chemistry and Molecular Spectroscopy (LASKEMO) for funding.
Abstract
The development of microfluidic processes requires information-rich detection methods. Here we introduce the concept of remote detection exchange NMR spectroscopy (RD-EXSY), and show that, along with indirect spatial information extracted from time-of-flight data, it provides unique information about the active regions, reaction pathways, and intermediate products in a lab-on-a-chip reactor. Furthermore, we demonstrate that direct spatial resolution can be added to RD-EXSY efficiently by applying the principles of Hadamard spectroscopy.
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