Catching Bubbles: Targeting Ultrasound Microbubbles Using Bioorthogonal Inverse-Electron-Demand Diels–Alder Reactions†
Aimen Zlitni
Department of Chemistry and Chemical Biology, McMaster University, 1280 Main St W., Hamilton, Ont., L8S 4M1 (Canada)
Search for more papers by this authorNancy Janzen
Department of Chemistry and Chemical Biology, McMaster University, 1280 Main St W., Hamilton, Ont., L8S 4M1 (Canada)
Search for more papers by this authorDr. F. Stuart Foster
Department of Medical Biophysics, University of Toronto, Sunnybrook Hospital, Toronto, Ont. M4N S658 (Canada)
Search for more papers by this authorCorresponding Author
Dr. John F. Valliant
Department of Chemistry and Chemical Biology, McMaster University, 1280 Main St W., Hamilton, Ont., L8S 4M1 (Canada)
Department of Chemistry and Chemical Biology, McMaster University, 1280 Main St W., Hamilton, Ont., L8S 4M1 (Canada)Search for more papers by this authorAimen Zlitni
Department of Chemistry and Chemical Biology, McMaster University, 1280 Main St W., Hamilton, Ont., L8S 4M1 (Canada)
Search for more papers by this authorNancy Janzen
Department of Chemistry and Chemical Biology, McMaster University, 1280 Main St W., Hamilton, Ont., L8S 4M1 (Canada)
Search for more papers by this authorDr. F. Stuart Foster
Department of Medical Biophysics, University of Toronto, Sunnybrook Hospital, Toronto, Ont. M4N S658 (Canada)
Search for more papers by this authorCorresponding Author
Dr. John F. Valliant
Department of Chemistry and Chemical Biology, McMaster University, 1280 Main St W., Hamilton, Ont., L8S 4M1 (Canada)
Department of Chemistry and Chemical Biology, McMaster University, 1280 Main St W., Hamilton, Ont., L8S 4M1 (Canada)Search for more papers by this authorFinancial support for this research was provided by the Natural Sciences and Engineering Research Council (NSERC) of Canada, The Ontario Ministry of Research and Innovation, the Ontario Research Fund (grant no. RE03-051), and the Canadian Cancer Society (grant no. 2011-700896). The authors also acknowledge Frederick R. Roberts and VisualSonics for their technical support.
Graphical Abstract
Bläschen fangen: Tetrazin-funktionalisierte Mikrobläschen wurden für die Nutzung als Ultraschall-Kontrastmittel aufgebaut und lokalisierten selektiv Zellen, die mit TCO-derivatisierten Antikörpern gegen VEGFR2 markiert waren. Diese Abfangmethode basiert auf Markierung und bioorthogonaler Chemie, und wurde in einer Durchflusskammer und in vivo durch Ultraschallaufnahmen von VEGFR2-positiven und -negativen Maustumormodellen validiert. TCO=trans-Cycloocten.
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