Iridium-Catalyzed Asymmetric Hydrogenation of α-Alkylidene Succinimides†
Yuanyuan Liu
School of Chemistry and Chemical Engineering, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai 200240 (China) http://wanbin.sjtu.edu.cn
Search for more papers by this authorCorresponding Author
Prof. Wanbin Zhang
School of Chemistry and Chemical Engineering, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai 200240 (China) http://wanbin.sjtu.edu.cn
School of Chemistry and Chemical Engineering, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai 200240 (China) http://wanbin.sjtu.edu.cn===Search for more papers by this authorYuanyuan Liu
School of Chemistry and Chemical Engineering, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai 200240 (China) http://wanbin.sjtu.edu.cn
Search for more papers by this authorCorresponding Author
Prof. Wanbin Zhang
School of Chemistry and Chemical Engineering, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai 200240 (China) http://wanbin.sjtu.edu.cn
School of Chemistry and Chemical Engineering, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai 200240 (China) http://wanbin.sjtu.edu.cn===Search for more papers by this authorThis work was partially supported by the National Natural Science Foundation of China (20972095, 21172143 and 21232004), the Science and Technology Commission of Shanghai Municipality (09JC1407800), Nippon Chemical Industrial Co., Ltd., and Shanghai Jiao Tong University. We thank Prof. Tsuneo Imamoto and Dr. Masashi Sugiya for helpful discussions. Our thanks also go to the Instrumental Analysis Center of Shanghai Jiao Tong University.
Graphical Abstract
Chirale Succinimid-Derivate sind durch die Titelreaktion mit ausgezeichneten Ausbeuten und Enantioselektivitäten schon bei Zusatz einer geringen Katalysatormenge von 0.05 Mol-% unter milden Bedingungen zugänglich. Wichtige Strukturmotive aus Natur- und Wirkstoffen, namentlich chirale 3-Benzylpyrrolidine und 1-Hydroxypyrrolidin-2,5-dione, konnten problemlos erhalten werden. BARF−=Tetrakis[3,5-bis(trifluormethyl)phenyl]borat.
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