Copper-Catalyzed Oxidative Coupling of Alkenes with Aldehydes: Direct Access to α,β-Unsaturated Ketones†
Jing Wang
College of Chemistry and Molecular Sciences, Wuhan University, Wuhan 430072, Hubei (P. R. China) http://www.chem.whu.edu.cn/GCI_WebSite/
These authors contributed equally to this work.
Search for more papers by this authorDr. Chao Liu
College of Chemistry and Molecular Sciences, Wuhan University, Wuhan 430072, Hubei (P. R. China) http://www.chem.whu.edu.cn/GCI_WebSite/
These authors contributed equally to this work.
Search for more papers by this authorJiwen Yuan
College of Chemistry and Molecular Sciences, Wuhan University, Wuhan 430072, Hubei (P. R. China) http://www.chem.whu.edu.cn/GCI_WebSite/
Search for more papers by this authorCorresponding Author
Prof. Aiwen Lei
College of Chemistry and Molecular Sciences, Wuhan University, Wuhan 430072, Hubei (P. R. China) http://www.chem.whu.edu.cn/GCI_WebSite/
Key Laboratory of Combinatorial Biosynthesis and Drug Discovery (Wuhan University), Ministry of Education, and Wuhan University School of Pharmaceutical Sciences, Wuhan, 430071 (P. R. China)
College of Chemistry and Molecular Sciences, Wuhan University, Wuhan 430072, Hubei (P. R. China) http://www.chem.whu.edu.cn/GCI_WebSite/===Search for more papers by this authorJing Wang
College of Chemistry and Molecular Sciences, Wuhan University, Wuhan 430072, Hubei (P. R. China) http://www.chem.whu.edu.cn/GCI_WebSite/
These authors contributed equally to this work.
Search for more papers by this authorDr. Chao Liu
College of Chemistry and Molecular Sciences, Wuhan University, Wuhan 430072, Hubei (P. R. China) http://www.chem.whu.edu.cn/GCI_WebSite/
These authors contributed equally to this work.
Search for more papers by this authorJiwen Yuan
College of Chemistry and Molecular Sciences, Wuhan University, Wuhan 430072, Hubei (P. R. China) http://www.chem.whu.edu.cn/GCI_WebSite/
Search for more papers by this authorCorresponding Author
Prof. Aiwen Lei
College of Chemistry and Molecular Sciences, Wuhan University, Wuhan 430072, Hubei (P. R. China) http://www.chem.whu.edu.cn/GCI_WebSite/
Key Laboratory of Combinatorial Biosynthesis and Drug Discovery (Wuhan University), Ministry of Education, and Wuhan University School of Pharmaceutical Sciences, Wuhan, 430071 (P. R. China)
College of Chemistry and Molecular Sciences, Wuhan University, Wuhan 430072, Hubei (P. R. China) http://www.chem.whu.edu.cn/GCI_WebSite/===Search for more papers by this authorThis work was supported by the 973 Program (2012CB725302), the National Natural Science Foundation of China (21025206 and 21272180), and the China Postdoctoral Science Foundation funded project (2012M521458). We are also grateful for the support from the Program for Changjiang Scholars and Innovative Research Team in University (IRT1030).
Graphical Abstract
Es wird radikalisch: Die erste kupferkatalysierte oxidative Kupplung von Alkenen mit verschiedenartigen Aldehyden liefert α,β-ungesättigte Ketone. Mechanistische Studien ergeben, dass die Reaktion vermutlich über einen Einelektronentransfer verläuft.
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