Catalytic Hydrogenation of Amides to Amines under Mild Conditions†
Dipl.-Chem. Mario Stein
Institut für Organische Chemie und Biochemie, Freiburg, Albertstrasse 21, 79104 Freiburg (Germany)
Search for more papers by this authorCorresponding Author
Prof. Dr. Bernhard Breit
Institut für Organische Chemie und Biochemie, Freiburg, Albertstrasse 21, 79104 Freiburg (Germany)
Institut für Organische Chemie und Biochemie, Freiburg, Albertstrasse 21, 79104 Freiburg (Germany)===Search for more papers by this authorDipl.-Chem. Mario Stein
Institut für Organische Chemie und Biochemie, Freiburg, Albertstrasse 21, 79104 Freiburg (Germany)
Search for more papers by this authorCorresponding Author
Prof. Dr. Bernhard Breit
Institut für Organische Chemie und Biochemie, Freiburg, Albertstrasse 21, 79104 Freiburg (Germany)
Institut für Organische Chemie und Biochemie, Freiburg, Albertstrasse 21, 79104 Freiburg (Germany)===Search for more papers by this authorThis work was supported by the DFG, the International Research Training Group “Catalysts and Catalytic Reactions for Organic Synthesis” (IRTG 1038) and the Krupp Foundation. We thank BASF SE, Umicore, Chemtura, and Wacker for generous gifts of chemicals, especially BASF SE for the supply of catalysts. We thank Dr. M. Keller, Dr. R. Thomann, Dr. J. Wörth and C. Warth for analytical help, and K. Wenz for assistance in functionalized amide synthesis and catalysis.
Graphical Abstract
Unter (nicht besonders viel) Druck: Ein allgemeines Verfahren zur hochselektiven Hydrierung tertiärer und sekundärer Amide zu Aminen mit einem Dimetall-Pd-Re-Katalysator wurde entwickelt. Die Reaktion läuft unter niedrigem Druck und bei relativ niedriger Temperatur ab. Mit diesem Verfahren haben Organiker eine einfache und verlässliche Synthese von Aminen in Händen.
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