Volume 123, Issue 45 pp. 10874-10877

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The Generation of Antimicrobial Peptide Activity: A Trade-off between Charge and Aggregation?^†

Dr. Marc Torrent,

Dr. Marc Torrent

Department of Experimental and Health Sciences, Universitat Pompeu Fabra, Dr. Aiguader 88, 08003 Barcelona (Spain)

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Javier Valle,

Javier Valle

Department of Experimental and Health Sciences, Universitat Pompeu Fabra, Dr. Aiguader 88, 08003 Barcelona (Spain)

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Prof. M. Victòria Nogués,

Prof. M. Victòria Nogués

Department of Biochemistry and Molecular Biology, Universitat Autònoma de Barcelona, Biosciences Faculty, Building C, 08193 Barcelona (Spain)

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Dr. Ester Boix,

Dr. Ester Boix

Department of Biochemistry and Molecular Biology, Universitat Autònoma de Barcelona, Biosciences Faculty, Building C, 08193 Barcelona (Spain)

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Prof. David Andreu,

Corresponding Author

Prof. David Andreu

[email protected]

Department of Experimental and Health Sciences, Universitat Pompeu Fabra, Dr. Aiguader 88, 08003 Barcelona (Spain)

Department of Experimental and Health Sciences, Universitat Pompeu Fabra, Dr. Aiguader 88, 08003 Barcelona (Spain)Search for more papers by this author

Dr. Marc Torrent,

Dr. Marc Torrent

Department of Experimental and Health Sciences, Universitat Pompeu Fabra, Dr. Aiguader 88, 08003 Barcelona (Spain)

Search for more papers by this author

Javier Valle,

Javier Valle

Department of Experimental and Health Sciences, Universitat Pompeu Fabra, Dr. Aiguader 88, 08003 Barcelona (Spain)

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Prof. M. Victòria Nogués,

Prof. M. Victòria Nogués

Department of Biochemistry and Molecular Biology, Universitat Autònoma de Barcelona, Biosciences Faculty, Building C, 08193 Barcelona (Spain)

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Dr. Ester Boix,

Dr. Ester Boix

Department of Biochemistry and Molecular Biology, Universitat Autònoma de Barcelona, Biosciences Faculty, Building C, 08193 Barcelona (Spain)

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Prof. David Andreu,

Corresponding Author

Prof. David Andreu

[email protected]

Department of Experimental and Health Sciences, Universitat Pompeu Fabra, Dr. Aiguader 88, 08003 Barcelona (Spain)

Department of Experimental and Health Sciences, Universitat Pompeu Fabra, Dr. Aiguader 88, 08003 Barcelona (Spain)Search for more papers by this author

First published: 16 September 2011

https://doi.org/10.1002/ange.201103589

Citations: 8

^†

M.T. is the recipient of a postdoctoral grant from Alianza Cuatro Universidades (Spain). This work was supported by the European Union (HEALTH-F3-2008-223414), the Spanish Ministry of Science and Innovation (BIO2008-04487-CO3-02, BFU2009-09371), and the Generalitat de Catalunya (SGR2009-494, SGR2009-795).

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Graphical Abstract

Molekulare Evolution: Antimikrobielle Peptide (AMPs) können von amyloidanfälligen Regionen abgeleitet werden, indem man kationische Reste an privilegierten Positionen einführt (siehe Bild). 24 neue, von Amyloid abgeleitete AMPs wurden entworfen und getestet, und die Wahrscheinlichkeit für die Evolution von amyloidanfälligen Proteinregionen mit fehlender antimikrobieller Aktivität in potente antimikrobielle Domänen wurde untersucht.

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The Generation of Antimicrobial Peptide Activity: A Trade-off between Charge and Aggregation?^†