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Carpe Diubiquitin^†

Dr. Langdon J. Martin

Department of Biochemistry, 433 Babcock Drive, University of Wisconsin-Madison, Madison, WI 53706 (USA), Fax: (+1) 1-608-890-2583 http://www.biochem.wisc.edu/faculty/raines/lab

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Prof. Ronald T. Raines,

Corresponding Author

Prof. Ronald T. Raines

[email protected]

Department of Biochemistry, 433 Babcock Drive, University of Wisconsin-Madison, Madison, WI 53706 (USA), Fax: (+1) 1-608-890-2583 http://www.biochem.wisc.edu/faculty/raines/lab

Department of Chemistry, 1101 University Avenue, University of Wisconsin-Madison, Madison, WI 53706 (USA)

Department of Biochemistry, 433 Babcock Drive, University of Wisconsin-Madison, Madison, WI 53706 (USA), Fax: (+1) 1-608-890-2583 http://www.biochem.wisc.edu/faculty/raines/lab Search for more papers by this author

Dr. Langdon J. Martin,

Dr. Langdon J. Martin

Department of Biochemistry, 433 Babcock Drive, University of Wisconsin-Madison, Madison, WI 53706 (USA), Fax: (+1) 1-608-890-2583 http://www.biochem.wisc.edu/faculty/raines/lab

Search for more papers by this author

Prof. Ronald T. Raines,

Corresponding Author

Prof. Ronald T. Raines

[email protected]

Department of Biochemistry, 433 Babcock Drive, University of Wisconsin-Madison, Madison, WI 53706 (USA), Fax: (+1) 1-608-890-2583 http://www.biochem.wisc.edu/faculty/raines/lab

Department of Chemistry, 1101 University Avenue, University of Wisconsin-Madison, Madison, WI 53706 (USA)

First published: 04 November 2010

https://doi.org/10.1002/ange.201005946

Citations: 9

^†

L.J.M. dankt den NIH für ein Promotionsstipendium (F32 GM087097). Unsere Arbeiten zur Proteinchemie werden durch Fördermittel der NIH (R01 GM044783) unterstützt.

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Graphical Abstract

Viele Wege führen zum Ziel: Ubiquitinierungen verlaufen über die Bildung einer unüblichen Isopeptidbindung zwischen dem ε-Stickstoffatom eines Lysinrestes im Zielprotein und der C-terminalen Carboxygruppe von Ubiquitin. Mehrere komplementäre Syntheseansätze haben die Herstellung von Diubiquitinketten in Mengen ermöglicht, die für Struktur-Funktions-Analysen taugen, und fanden ihren Höhepunkt in der chemischen Totalsynthese aller sieben Diubiquitinketten.

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Volume122, Issue48

November 22, 2010

Pages 9226-9228

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Carpe Diubiquitin^†

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Carpe Diubiquitin^†