Radical Cyclization of N-Acylcyanamides: Total Synthesis of Luotonin A†
Aurore Servais
Laboratoire de Chimie Organique, UMR CNRS 7611, Institut de Chimie Moléculaire, FR 2769, Université Pierre et Marie Curie, Paris 6, case 229, 4, place Jussieu, 75252 Paris, France, Fax: (+33) 1-4427-7360
Search for more papers by this authorMériam Azzouz
Laboratoire de Chimie Organique, UMR CNRS 7611, Institut de Chimie Moléculaire, FR 2769, Université Pierre et Marie Curie, Paris 6, case 229, 4, place Jussieu, 75252 Paris, France, Fax: (+33) 1-4427-7360
Search for more papers by this authorDavid Lopes
Laboratoire de Chimie Organique, UMR CNRS 7611, Institut de Chimie Moléculaire, FR 2769, Université Pierre et Marie Curie, Paris 6, case 229, 4, place Jussieu, 75252 Paris, France, Fax: (+33) 1-4427-7360
Search for more papers by this authorChristine Courillon Prof.
Laboratoire de Chimie Organique, UMR CNRS 7611, Institut de Chimie Moléculaire, FR 2769, Université Pierre et Marie Curie, Paris 6, case 229, 4, place Jussieu, 75252 Paris, France, Fax: (+33) 1-4427-7360
Search for more papers by this authorMax Malacria Prof.
Laboratoire de Chimie Organique, UMR CNRS 7611, Institut de Chimie Moléculaire, FR 2769, Université Pierre et Marie Curie, Paris 6, case 229, 4, place Jussieu, 75252 Paris, France, Fax: (+33) 1-4427-7360
Search for more papers by this authorAurore Servais
Laboratoire de Chimie Organique, UMR CNRS 7611, Institut de Chimie Moléculaire, FR 2769, Université Pierre et Marie Curie, Paris 6, case 229, 4, place Jussieu, 75252 Paris, France, Fax: (+33) 1-4427-7360
Search for more papers by this authorMériam Azzouz
Laboratoire de Chimie Organique, UMR CNRS 7611, Institut de Chimie Moléculaire, FR 2769, Université Pierre et Marie Curie, Paris 6, case 229, 4, place Jussieu, 75252 Paris, France, Fax: (+33) 1-4427-7360
Search for more papers by this authorDavid Lopes
Laboratoire de Chimie Organique, UMR CNRS 7611, Institut de Chimie Moléculaire, FR 2769, Université Pierre et Marie Curie, Paris 6, case 229, 4, place Jussieu, 75252 Paris, France, Fax: (+33) 1-4427-7360
Search for more papers by this authorChristine Courillon Prof.
Laboratoire de Chimie Organique, UMR CNRS 7611, Institut de Chimie Moléculaire, FR 2769, Université Pierre et Marie Curie, Paris 6, case 229, 4, place Jussieu, 75252 Paris, France, Fax: (+33) 1-4427-7360
Search for more papers by this authorMax Malacria Prof.
Laboratoire de Chimie Organique, UMR CNRS 7611, Institut de Chimie Moléculaire, FR 2769, Université Pierre et Marie Curie, Paris 6, case 229, 4, place Jussieu, 75252 Paris, France, Fax: (+33) 1-4427-7360
Search for more papers by this authorM.M. is a senior member of the Institut Universitaire de France. The authors thank IUF, Ministère de la Recherche, CNRS, and Institut de Recherche Pierre Fabre (grant to A.S.) for financial support. Dr. Emmanuel Lacôte (UPMC-CNRS) is gratefully acknowledged for his suggestions concerning the organization of this manuscript.
Graphical Abstract
Als Vorstufe für eine Radikalkettenkaskade liefern N-Acylcyanamide Amid-Iminyl-Radikale, die – bei geeigneter Substitution – schließlich zu Pyrrolochinazolinen reagieren können. Die Vielseitigkeit dieser neuen Radikalacceptoren belegen die Bildung von N-Heterocyclen mit einer breiten Strukturvielfalt und die Totalsynthese von Luotonin A.
Supporting Information
Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2001/2007/z602940_s.pdf or from the author.
Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
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