Direct Organocatalytic and Highly Enantio- and Diastereoselective Mannich Reactions of α-Substituted α-Cyanoacetates†
Thomas B. Poulsen
The Danish National Research Foundation, Center for Catalysis, Department of Chemistry, Aarhus University, 8000 Aarhus C, Denmark, Fax: (+45) 8919-6199
Search for more papers by this authorCarlos Alemparte Dr.
The Danish National Research Foundation, Center for Catalysis, Department of Chemistry, Aarhus University, 8000 Aarhus C, Denmark, Fax: (+45) 8919-6199
Search for more papers by this authorSteen Saaby Dr.
The Danish National Research Foundation, Center for Catalysis, Department of Chemistry, Aarhus University, 8000 Aarhus C, Denmark, Fax: (+45) 8919-6199
Search for more papers by this authorMarco Bella Dr.
The Danish National Research Foundation, Center for Catalysis, Department of Chemistry, Aarhus University, 8000 Aarhus C, Denmark, Fax: (+45) 8919-6199
Search for more papers by this authorKarl Anker Jørgensen Prof. Dr.
The Danish National Research Foundation, Center for Catalysis, Department of Chemistry, Aarhus University, 8000 Aarhus C, Denmark, Fax: (+45) 8919-6199
Search for more papers by this authorThomas B. Poulsen
The Danish National Research Foundation, Center for Catalysis, Department of Chemistry, Aarhus University, 8000 Aarhus C, Denmark, Fax: (+45) 8919-6199
Search for more papers by this authorCarlos Alemparte Dr.
The Danish National Research Foundation, Center for Catalysis, Department of Chemistry, Aarhus University, 8000 Aarhus C, Denmark, Fax: (+45) 8919-6199
Search for more papers by this authorSteen Saaby Dr.
The Danish National Research Foundation, Center for Catalysis, Department of Chemistry, Aarhus University, 8000 Aarhus C, Denmark, Fax: (+45) 8919-6199
Search for more papers by this authorMarco Bella Dr.
The Danish National Research Foundation, Center for Catalysis, Department of Chemistry, Aarhus University, 8000 Aarhus C, Denmark, Fax: (+45) 8919-6199
Search for more papers by this authorKarl Anker Jørgensen Prof. Dr.
The Danish National Research Foundation, Center for Catalysis, Department of Chemistry, Aarhus University, 8000 Aarhus C, Denmark, Fax: (+45) 8919-6199
Search for more papers by this authorThis work was made possible by a grant from The Danish National Research Foundation. We are grateful to Dr. Jacob Overgaard for X-ray crystallographic analysis.
Graphical Abstract
Metallfreie Katalyse: Hoch funktionalisierte Moleküle mit zwei benachbarten Stereozentren sind mit einem käuflichen Organokatalysator einfach, in hoher Ausbeute und mit hoher Enantio- und Diastereoselektivität zugänglich (siehe Schema). Die leicht zu entfernende Boc-Schutzgruppe im Produkt ist ein zusätzlicher Vorteil dieser Methode.
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