Catalytic Asymmetric Mercuriocyclization of γ-Hydroxy-cis-Alkenes†
Sung Ho Kang Prof. Dr.
Center for Molecular Design and Synthesis, Department of Chemistry, School of Molecular Science (BK21), Korea Advanced Institute of Science and Technology, Daejeon 305-701, Korea, Fax: (+82) 42-869-2810
Search for more papers by this authorMihyong Kim Dr.
Center for Molecular Design and Synthesis, Department of Chemistry, School of Molecular Science (BK21), Korea Advanced Institute of Science and Technology, Daejeon 305-701, Korea, Fax: (+82) 42-869-2810
Search for more papers by this authorSuk Youn Kang Dr.
Center for Molecular Design and Synthesis, Department of Chemistry, School of Molecular Science (BK21), Korea Advanced Institute of Science and Technology, Daejeon 305-701, Korea, Fax: (+82) 42-869-2810
Search for more papers by this authorSung Ho Kang Prof. Dr.
Center for Molecular Design and Synthesis, Department of Chemistry, School of Molecular Science (BK21), Korea Advanced Institute of Science and Technology, Daejeon 305-701, Korea, Fax: (+82) 42-869-2810
Search for more papers by this authorMihyong Kim Dr.
Center for Molecular Design and Synthesis, Department of Chemistry, School of Molecular Science (BK21), Korea Advanced Institute of Science and Technology, Daejeon 305-701, Korea, Fax: (+82) 42-869-2810
Search for more papers by this authorSuk Youn Kang Dr.
Center for Molecular Design and Synthesis, Department of Chemistry, School of Molecular Science (BK21), Korea Advanced Institute of Science and Technology, Daejeon 305-701, Korea, Fax: (+82) 42-869-2810
Search for more papers by this authorThis work was supported by CMDS and the Brain Korea 21 Project.
Graphical Abstract
2-Monosubstituierte Tetrahydrofurane 2 entstehen mit 73–95 % ee bei der katalytischen enantioselektiven Mercuriocyclisierung von γ-Hydroxy-(Z)-alkenen 1 mit Hg(OAc)2 in Gegenwart von HgII, das mit dem Bisoxazolin 3 komplexiert ist. Der chirale Komplex wurde aus Hg(tfa)2 (0.2 Äquiv.) und 3 (0.3 Äquiv.) hergestellt. Die MeOH-Menge hat einen großen Einfluss auf die Enantioselektivität.
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