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Selektive Wechselwirkung der Dipeptide L-Phe-D-Pro und D-Phe-L-Pro mit β-Cyclodextrin^†

Corresponding Author

Milana Maletic Dipl.-Chem.

Department of Chemistry, Columbia University New York. NY 10027 (USA) Telefax: Int. +212/854–5429

Department of Chemistry, Columbia University New York. NY 10027 (USA) Telefax: Int. +212/854–5429Search for more papers by this author

Helma Wennemers,

Corresponding Author

Helma Wennemers

Department of Chemistry, Columbia University New York. NY 10027 (USA) Telefax: Int. +212/854–5429

Department of Chemistry, Columbia University New York. NY 10027 (USA) Telefax: Int. +212/854–5429Search for more papers by this author

Dr. D. Quentin McDonald,

Dr. D. Quentin McDonald

Department of Chemistry, Columbia University New York. NY 10027 (USA) Telefax: Int. +212/854–5429

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Prof. Ronald Breslow Dipl.-Chem.,

Prof. Ronald Breslow Dipl.-Chem.

Department of Chemistry, Columbia University New York. NY 10027 (USA) Telefax: Int. +212/854–5429

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Prof. W. Clark Still,

Prof. W. Clark Still

[email protected]

Department of Chemistry, Columbia University New York. NY 10027 (USA) Telefax: Int. +212/854–5429

Search for more papers by this author

Milana Maletic Dipl.-Chem.,

Corresponding Author

Milana Maletic Dipl.-Chem.

Department of Chemistry, Columbia University New York. NY 10027 (USA) Telefax: Int. +212/854–5429

Department of Chemistry, Columbia University New York. NY 10027 (USA) Telefax: Int. +212/854–5429Search for more papers by this author

Helma Wennemers,

Corresponding Author

Helma Wennemers

Department of Chemistry, Columbia University New York. NY 10027 (USA) Telefax: Int. +212/854–5429

Department of Chemistry, Columbia University New York. NY 10027 (USA) Telefax: Int. +212/854–5429Search for more papers by this author

Dr. D. Quentin McDonald,

Dr. D. Quentin McDonald

Department of Chemistry, Columbia University New York. NY 10027 (USA) Telefax: Int. +212/854–5429

Search for more papers by this author

Prof. Ronald Breslow Dipl.-Chem.,

Prof. Ronald Breslow Dipl.-Chem.

Department of Chemistry, Columbia University New York. NY 10027 (USA) Telefax: Int. +212/854–5429

Search for more papers by this author

Prof. W. Clark Still,

Prof. W. Clark Still

[email protected]

Department of Chemistry, Columbia University New York. NY 10027 (USA) Telefax: Int. +212/854–5429

Search for more papers by this author

First published: 15. Juli 1996

https://doi.org/10.1002/ange.19961081311

Citations: 13

^†

Diese Arbeit wurde von der National Science Foundation (Grant CHE 9544253) (WCS), den National Institutes of Health und dem Office of Naval Research (RB) gefördert. HW dankt dem Fonds der Chemischen Industrie für ein Kékulé-Stipendium. MM und HW haben zu gleichen Teilen zu der vorliegenden Arbeit beigetragen.

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Abstract

Kombinatorische Chemie ermöglichte den Nachweis einer hochselektiven Wechselwirkung der Dipeptide L-Phe-D-Pro und D-Phe-L-Pro mit β-Cyclodextrin. NMR-spektroskopische Studien und Molecular Modeling gaben Aufschluß über die Bindungsgeometrie des Komplexes (siehe Bild rechts) und lieferten eine Erklärung für die Selektion dieser beiden Dipeptide aus dem Repertoire der verwendeten Tripeptidbibliothek.

References

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Volume108, Issue13-14

15. Juli 1996

Pages 1594-1596

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German version

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Selektive Wechselwirkung der Dipeptide L-Phe-D-Pro und D-Phe-L-Pro mit β-Cyclodextrin^†

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Selektive Wechselwirkung der Dipeptide L-Phe-D-Pro und D-Phe-L-Pro mit β-Cyclodextrin†

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Selektive Wechselwirkung der Dipeptide L-Phe-D-Pro und D-Phe-L-Pro mit β-Cyclodextrin^†