Original Article

Full Access

Striatal hypometabolism distinguishes striatonigral degeneration from Parkinson's disease

Corresponding Author

Dr. D. Eidelberg MD

Department of Neurology, North Shore University Hospital-Cornell University Medical College, Manhasset

Department of Neurology, North Shore University Hospital-Cornell University Medical College, 300 Community Drive, Manhasset, NY 11030Search for more papers by this author

S. Takikawa MD,

S. Takikawa MD

Department of Neurology, North Shore University Hospital-Cornell University Medical College, Manhasset

Search for more papers by this author

J. R. Moeller PhD,

J. R. Moeller PhD

Department of Biological Psychiatry, Columbia College of Physicians and Surgeons, New York

Search for more papers by this author

V. Dhawan PhD,

V. Dhawan PhD

Department of Neurology, North Shore University Hospital-Cornell University Medical College, Manhasset

Search for more papers by this author

K. Redington MD,

K. Redington MD

Department of Neurology, North Shore University Hospital-Cornell University Medical College, Manhasset

Search for more papers by this author

T. Chaly PhD,

T. Chaly PhD

Department of Medicine, North Shore University Hospital-Cornell University Medical College, Manhasset

Search for more papers by this author

W. Robeson MSc,

W. Robeson MSc

Department of Medicine, North Shore University Hospital-Cornell University Medical College, Manhasset

Search for more papers by this author

J. R. Dahl PhD,

J. R. Dahl PhD

Department of Medicine, North Shore University Hospital-Cornell University Medical College, Manhasset

Search for more papers by this author

D. Margouleff MD,

D. Margouleff MD

Department of Medicine, North Shore University Hospital-Cornell University Medical College, Manhasset

Search for more papers by this author

E. Fazzini DO, PhD,

E. Fazzini DO, PhD

Department of Neurology, Hospital for Joint Diseases, New York

Search for more papers by this author

S. Przedborski MD,

S. Przedborski MD

Department of Neurology, Neurological Institute, New York, NY

Search for more papers by this author

S. Fahn MD,

S. Fahn MD

Department of Neurology, Neurological Institute, New York, NY

Search for more papers by this author

Dr. D. Eidelberg MD,

Corresponding Author

Dr. D. Eidelberg MD

Department of Neurology, North Shore University Hospital-Cornell University Medical College, Manhasset

Department of Neurology, North Shore University Hospital-Cornell University Medical College, 300 Community Drive, Manhasset, NY 11030Search for more papers by this author

S. Takikawa MD,

S. Takikawa MD

Department of Neurology, North Shore University Hospital-Cornell University Medical College, Manhasset

Search for more papers by this author

J. R. Moeller PhD,

J. R. Moeller PhD

Department of Biological Psychiatry, Columbia College of Physicians and Surgeons, New York

Search for more papers by this author

V. Dhawan PhD,

V. Dhawan PhD

Department of Neurology, North Shore University Hospital-Cornell University Medical College, Manhasset

Search for more papers by this author

K. Redington MD,

K. Redington MD

Department of Neurology, North Shore University Hospital-Cornell University Medical College, Manhasset

Search for more papers by this author

T. Chaly PhD,

T. Chaly PhD

Department of Medicine, North Shore University Hospital-Cornell University Medical College, Manhasset

Search for more papers by this author

W. Robeson MSc,

W. Robeson MSc

Department of Medicine, North Shore University Hospital-Cornell University Medical College, Manhasset

Search for more papers by this author

J. R. Dahl PhD,

J. R. Dahl PhD

Department of Medicine, North Shore University Hospital-Cornell University Medical College, Manhasset

Search for more papers by this author

D. Margouleff MD,

D. Margouleff MD

Department of Medicine, North Shore University Hospital-Cornell University Medical College, Manhasset

Search for more papers by this author

E. Fazzini DO, PhD,

E. Fazzini DO, PhD

Department of Neurology, Hospital for Joint Diseases, New York

Search for more papers by this author

S. Przedborski MD,

S. Przedborski MD

Department of Neurology, Neurological Institute, New York, NY

Search for more papers by this author

S. Fahn MD,

S. Fahn MD

Department of Neurology, Neurological Institute, New York, NY

Search for more papers by this author

First published: May 1993

https://doi.org/10.1002/ana.410330517

Citations: 115

About

PDF

Tools

Share a link

Email
Wechat
Bluesky

Abstract

Regional and global metabolic rates for glucose were estimated using ¹⁸F-fluorodeoxyglucose and positron emission tomography in 10 patients with a clinical likelihood of striatonigral degeneration (2 men and 8 women; mean age, 61.8 ± 6.9 years; mean disease duration, 4.7 ± 2.2 years; mean Hoehn and Yahr score, 3.5 ± 0.8). Measures of brain glucose metabolism in these patients were compared with those for 10 age-matched normal volunteers, 10 disease severity–matched patients with Parkinson's disease(PD), and 10 disease duration–matched patients with PD. Normalized glucose metabolism was significantly reduced in the caudate(p < 0.03) and putamen (p < 0.003) as compared with that in normal and PD control subjects, and discriminated patients with striatonigral degeneration from control subjects (p < 0.002). Putamenal hypometabolism in patients with striatonigral degeneration correlated significantly with quantitaive ratings of motor disability (p < 0.02). These results suggest that quantitative ¹⁸F-fluorodeoxyglucose positron emission tomography techniques may be useful in supporting a diagnosis of striatonigral degeneration in life, and in objectively assessing disease severity and potential therapeutic interventions.

References

1 Adams RD, Van Bogaert L, Vander Ecken H. Striato-nigral degeneration. J Neuropathol Exp Neurol 1964; 23: 584–608
CAS PubMed Web of Science® Google Scholar
2 Gibb W R G. Neuropathology of Parkinson's disease and related syndromes. Neurol Clin 1992; 10: 361–376
10.1016/S0733-8619(18)30215-9
CAS PubMed Web of Science® Google Scholar
3 Fearnley JM, Lees AJ. Stratonigral degeneration: a clinicopathological study. Brain 1990; 113: 1823–1842
10.1093/brain/113.6.1823
PubMed Web of Science® Google Scholar
4 Stacy M, Jankovic J. Differential diagnosis of Parkinson's disease and the parkinsonism plus syndromes. Neurologic Clin 1992; 10: 341–360
10.1016/S0733-8619(18)30214-7
CAS PubMed Web of Science® Google Scholar
5 Fahn S, Elton RL, The UPDRS Development Committee. Unified Parkinson Disease Rating Scale. In: S Fahn, C D Marsden, D Calne, et al, eds. Recent developments in Parkinson's disease, vol 2. Floral Park, NJ: McMillan, 1987: 293–304
Google Scholar
6 Robeson W, Dhawan V, Babchyck B, et al. Super PETT 3000 time-of-flight PET tomograph: optimization of factors affecting quantitation. IEEE Trans Nucl Sci 1993 (in press)
Google Scholar
7 Kearfott KJ, Rottenberg DA, Knowles R J R. A new headholder for PET, CT and NMR imaging. J Comput Assist Tomogr 1984; 8: 1217–1220
10.1097/00004728-198412000-00042
CAS PubMed Web of Science® Google Scholar
8 Chaly T, Mattacchieri R, Velez JW. A large scale manual production of [¹⁸F]FDG using a synthetic unit made of sterile disposable components and operated by a master slave manipulator. Appl Radiat sot 1990; 41: 29–34
10.1016/0883-2889(90)90126-2
CAS Web of Science® Google Scholar
9 Evans AC, Diksic M, Yamamoto YL, et al. Effect of vascular activity in the determination rate constants for the uptake of ¹⁸F-labelled 2-fluoro-2-deoxy-D-glucose; error analysis and normal values in older subjects. J Cereb Blood Flow Metab 1986; 6: 724–738
10.1038/jcbfm.1986.129
CAS PubMed Web of Science® Google Scholar
10 Phelps ME, Huang SC, Hoffman EJ, et al. Tomographic measurement of local cerebral glucose metabolic rate in humans with (¹⁸F) 2-fluoro-2-deoxy-D-glucose. Validation of method. Ann Neurol 1979; 6: 371–388
10.1002/ana.410060502
CAS PubMed Web of Science® Google Scholar
11 Dhawan V, Moeller JR, Strother SC, et al. Effect of selecting a fixed dephosphorylation rate on the estimation of rate constants and rCMRGlu from dynamic [¹⁸F]fluorodeoxyglucose/PET data. J Nucl Med 1989; 30: 1483–1488
CAS PubMed Web of Science® Google Scholar
12 Spetsieris P, Dhawan V, Margouleff D, Eidelberg D. A. versatile graphics-image processing package for imaging cerebral function. IEEE Comput Graph Appl 1993; 13: 15–26
10.1109/38.180113
Web of Science® Google Scholar
13 Talairach J, Tournoux P. Co-planar stereotaxic atlas of the human brain. New York: Thieme, 1988
Web of Science® Google Scholar
14 Anderson TW. An introduction to multivariate statistical analysis. New York: John Wiley, 1984
Google Scholar
15 O'Brien C, Sung JH, McGeachie RE, et al. Stratonigral degeneration: clinical, MRI, and pathologic correlation. Neurology 1990; 40: 710–711
10.1212/WNL.40.4.710
CAS PubMed Web of Science® Google Scholar
16 Drayer BP, Olanow W, Burger P, et al. MR Imaging of brain iron. Radiology 1986; 159: 493–498
10.1148/radiology.159.2.3961182
CAS PubMed Web of Science® Google Scholar
17 Olanow CW. Magnetic resonance imaging in parkinsonism. Neurol Clin 1992; 10: 405–420
10.1016/S0733-8619(18)30218-4
CAS PubMed Web of Science® Google Scholar
18 Stern MB, Braffman BH, Skolnick BE, et al. Magnetic resonance imaging in Parkinson's disease and parkinsonian syndromes. Neurology 1989; 36: 653–657
Google Scholar
19 Brooks DJ, Ibanez V, Sawle GV, et al. Striatal D₂ receptor status in patients with Parkinson's disease, stratonigral degeneration, and progressive supranuclear palsy, measured with ¹¹Craclopride and positron emission tomography. Ann Neurol 1992; 31: 184–192
10.1002/ana.410310209
CAS PubMed Web of Science® Google Scholar
20 Pickel VM, Beckley SC, Joh TH, et al. Ultrastructural immunocytochemical localization of tyrosine hydroxylase in the neostriatum. Brain Res 1981; 225: 373–385
10.1016/0006-8993(81)90843-X
CAS PubMed Web of Science® Google Scholar
21 De Volder AG, Francart J, Laterre C, et al. Decreased glucose utilization in the striatum and frontal lobe in probable stratonigral degeneration. Ann Neurol 1989; 26: 239–247
10.1002/ana.410260210
CAS PubMed Web of Science® Google Scholar
22 Otsuka M, Ichiya Y, Hosokawa S, et al. Striatal blood flow, glucose metabolism and ¹⁸F-dopa uptake: difference in Parkinson's disease and atypical parkinsonism. J Neurol Neurosurg Psychiatry 1991; 54: 898–904
10.1136/jnnp.54.10.898
CAS PubMed Web of Science® Google Scholar
23 D'Antona R, Baron JC, Samson Y, et al. Subcortical dementia. Frontal cortex hypometabolism detected by positron tomography in patients with progressive supranuclear palsy. Brain 1985; 108: 785–799
10.1093/brain/108.3.785
PubMed Web of Science® Google Scholar
24 Brotchie JM, Mitchell IJ, Sambrook MA, Crossman AR. Alleviation of parkinsonsim by antagonism of excitatory amino acid transmission in the medial segment of the globus pallidus in rat and Primate. Mov Disord 1991; 6: 133–138
10.1002/mds.870060208
CAS PubMed Web of Science® Google Scholar

Citing Literature

Volume33, Issue5

May 1993

Pages 518-527

Striatal hypometabolism distinguishes striatonigral degeneration from Parkinson's disease

Abstract

References

Citing Literature

References

Information

About Wiley Online Library

Help & Support

Opportunities

Connect with Wiley

Striatal hypometabolism distinguishes striatonigral degeneration from Parkinson's disease

Abstract

References

Citing Literature

References

Related

Information