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Tourette's syndrome: A neurochemical analysis of postmortem cortical brain tissue

Corresponding Author

Harvey S. Singer Dr., MD

Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD

Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, MD

Department of Neurology, Johns Hopkins Hospital, 600 N. Wolfe Street, Baltimore, MD 21205Search for more papers by this author

In-Hei Hahn BA,

In-Hei Hahn BA

Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD

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Edward Krowiak BA,

Edward Krowiak BA

Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD

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Eric Nelson BA,

Eric Nelson BA

Department of Psychiatry, Johns Hopkins University School of Medicine, Baltimore, MD

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Timothy Moran PhD,

Timothy Moran PhD

Department of Psychiatry, Johns Hopkins University School of Medicine, Baltimore, MD

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Harvey S. Singer Dr., MD,

Corresponding Author

Harvey S. Singer Dr., MD

Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD

Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, MD

Department of Neurology, Johns Hopkins Hospital, 600 N. Wolfe Street, Baltimore, MD 21205Search for more papers by this author

In-Hei Hahn BA,

In-Hei Hahn BA

Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD

Search for more papers by this author

Edward Krowiak BA,

Edward Krowiak BA

Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD

Search for more papers by this author

Eric Nelson BA,

Eric Nelson BA

Department of Psychiatry, Johns Hopkins University School of Medicine, Baltimore, MD

Search for more papers by this author

Timothy Moran PhD,

Timothy Moran PhD

Department of Psychiatry, Johns Hopkins University School of Medicine, Baltimore, MD

Search for more papers by this author

First published: April 1990

https://doi.org/10.1002/ana.410270415

Citations: 55

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Abstract

Postmortem frontal, temporal, and occipital regions of the brain from adult patients who had a diagnosis of Tourette's syndrome were analyzed for neurochemical alterations. In 3 of 4 TS-affected brains, the concentration of adenosine 3′,5′ -monophosphate (cyclic AMP) was reduced in all brain regions evaluated. This diminution in cyclic AMP was not associated with a significant change in the activity of the synthesizing enzyme, adenylate cyclase. No significant differences were identified for the neurotransmitter-synthesizing enzymes choline acetltransferase and glutamate decarboxylase. Concentrations of dopamine, norepinephrine, and the serotonin metabolite 5-hydroxyindoleacetic acid were not altered. Postsynaptic receptor-binding activity for muscarinic cholinergic ([³H] quinuclidiny1 benzilate) and beta receptors ([¹²⁵I]iodocyanopindolol) showed no generalized impairment. It is suggested that symptoms of Tourette's syndrome might be related to an abnormality within a second messenger system.

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Volume27, Issue4

April 1990

Pages 443-446

Tourette's syndrome: A neurochemical analysis of postmortem cortical brain tissue

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Tourette's syndrome: A neurochemical analysis of postmortem cortical brain tissue

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