Interleukin-12p40 genotype plays a role in the susceptibility to multiple sclerosis
Tineke Van Veen MSc
Department of Neurology
Department of Clinical Epidemiology and Biostatistics
Search for more papers by this authorJ. Bart A. Crusius MSc
Laboratory of Gastrointestinal Immunogenetics, VU Medical Centre, Amsterdam, The Netherlands
Search for more papers by this authorGerd Bouma MD, PhD
Laboratory of Gastrointestinal Immunogenetics, VU Medical Centre, Amsterdam, The Netherlands
Search for more papers by this authorA. Salvador Peña MD, PhD
Laboratory of Gastrointestinal Immunogenetics, VU Medical Centre, Amsterdam, The Netherlands
Search for more papers by this authorBernard M.J. Uitdehaag MD, PhD
Department of Neurology
Department of Clinical Epidemiology and Biostatistics
Search for more papers by this authorTineke Van Veen MSc
Department of Neurology
Department of Clinical Epidemiology and Biostatistics
Search for more papers by this authorJ. Bart A. Crusius MSc
Laboratory of Gastrointestinal Immunogenetics, VU Medical Centre, Amsterdam, The Netherlands
Search for more papers by this authorGerd Bouma MD, PhD
Laboratory of Gastrointestinal Immunogenetics, VU Medical Centre, Amsterdam, The Netherlands
Search for more papers by this authorA. Salvador Peña MD, PhD
Laboratory of Gastrointestinal Immunogenetics, VU Medical Centre, Amsterdam, The Netherlands
Search for more papers by this authorBernard M.J. Uitdehaag MD, PhD
Department of Neurology
Department of Clinical Epidemiology and Biostatistics
Search for more papers by this author
References
- 1 Van Boxel-Dezaire AHH, Hoff SCJ, van Oosten BW, et al. Decreased interleukin-10 and increased interleukin-12p40 mRNA are associated with disease activity and characterize different disease stages in multiple sclerosis. Ann Neurol 1999; 45: 695–703.
- 2 Brunda M. Interleukin-12. J Leukoc Biol 1994; 55: 280–288.
- 3 Huang D, Cancilla MR, Morahan G. Complete primary structure, chromosomal localisation, and definition of polymorphisms of the gene encoding the human interleukin-12p40 subunit. Genes Immun 2000; 1: 515–520.
- 4 Morahan G, Huang D, Ymer SI, et al. Linkage disequilibrium of a type I diabetes susceptibility locus with a regulatory IL12B allele. Nat Genet 2001; 27: 218–221.
- 5 Hall MA, McGlinn E, Coakley G, et al. Genetic polymorphism of IL-12p40 gene in immune-mediated disease. Genes Immun 2000; 1: 219–224.
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