Meningioma presenting with Cushing's syndrome: An unusual clinical presentation
Corresponding Author
Francesca Pecori Giraldi MD
Istituto Scientifico Ospedale San Luca Istituto Auxologico Italiano IRCCS, Chair of Endocrinology, University of Milan, Milan, Italy
Istituto Auxologico Italiano IRCCS, Ospedale San Luca, via Spagnoletto 3, 20149 Milan, ItalySearch for more papers by this authorMaria Rosa Terreni MD
Department of Pathology, IRCCS, San Raffaele, Italy
Search for more papers by this authorClaudia Andreotti MD
Department of Internal Medicine, IRCCS, San Raffaele, Italy
Search for more papers by this authorMarco Losa MD
Department of Neurosurgery, IRCCS, San Raffaele, Italy
Search for more papers by this authorRoberto Lanzi MD
Department of Internal Medicine, IRCCS, San Raffaele, Italy
Search for more papers by this authorAntonio E. Pontiroli MD
Ospedale San Paolo, University of Milan, Milan, Italy
Search for more papers by this authorFrancesco Cavagnini MD
Istituto Scientifico Ospedale San Luca Istituto Auxologico Italiano IRCCS, Chair of Endocrinology, University of Milan, Milan, Italy
Search for more papers by this authorCorresponding Author
Francesca Pecori Giraldi MD
Istituto Scientifico Ospedale San Luca Istituto Auxologico Italiano IRCCS, Chair of Endocrinology, University of Milan, Milan, Italy
Istituto Auxologico Italiano IRCCS, Ospedale San Luca, via Spagnoletto 3, 20149 Milan, ItalySearch for more papers by this authorMaria Rosa Terreni MD
Department of Pathology, IRCCS, San Raffaele, Italy
Search for more papers by this authorClaudia Andreotti MD
Department of Internal Medicine, IRCCS, San Raffaele, Italy
Search for more papers by this authorMarco Losa MD
Department of Neurosurgery, IRCCS, San Raffaele, Italy
Search for more papers by this authorRoberto Lanzi MD
Department of Internal Medicine, IRCCS, San Raffaele, Italy
Search for more papers by this authorAntonio E. Pontiroli MD
Ospedale San Paolo, University of Milan, Milan, Italy
Search for more papers by this authorFrancesco Cavagnini MD
Istituto Scientifico Ospedale San Luca Istituto Auxologico Italiano IRCCS, Chair of Endocrinology, University of Milan, Milan, Italy
Search for more papers by this authorAbstract
We report a patient with a meningioma presenting with Cushing's syndrome, an unprecedented paraneoplastic presentation. Molecular studies, bioassay, and high-performance liquid chromatography of tumor specimens demonstrated the synthesis and secretion of bioactive corticotropin-releasing hormone. To our knowledge, this appears to be the first report of a hormone-secreting meningioma and, further, the first clearly proven case of Cushing's syndrome due to ectopic corticotropin-releasing hormone secretion without concomitant corticotropin production. Ann Neurol 2003
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