Progressive hippocampal atrophy in chronic intractable temporal lobe epilepsy
Terence J. O'Brien MB BS, FRACP
Department of Neurology, Mayo Clinic, Rochester, MN
Search for more papers by this authorCorresponding Author
Elson L. So MD
Department of Neurology, Mayo Clinic, Rochester, MN
Section of Electroencephalography, Department of Neurology, Mayo Clinic, 200 First St SW, Rochester, MN 55905Search for more papers by this authorFredrick B. Meyer MD
Department of Neurosurgery, Mayo Clinic, Rochester, MN
Search for more papers by this authorJoseph E. Parisi MD
Department of Pathology, Mayo Clinic, Rochester, MN
Search for more papers by this authorClifford R. Jack MD
Department of Radiology, Mayo Clinic, Rochester, MN
Search for more papers by this authorTerence J. O'Brien MB BS, FRACP
Department of Neurology, Mayo Clinic, Rochester, MN
Search for more papers by this authorCorresponding Author
Elson L. So MD
Department of Neurology, Mayo Clinic, Rochester, MN
Section of Electroencephalography, Department of Neurology, Mayo Clinic, 200 First St SW, Rochester, MN 55905Search for more papers by this authorFredrick B. Meyer MD
Department of Neurosurgery, Mayo Clinic, Rochester, MN
Search for more papers by this authorJoseph E. Parisi MD
Department of Pathology, Mayo Clinic, Rochester, MN
Search for more papers by this authorClifford R. Jack MD
Department of Radiology, Mayo Clinic, Rochester, MN
Search for more papers by this authorAbstract
We report on a 28-year-old man with long-standing intractable complex partial and secondary generalized seizures, whose magnetic resonance imaging scans 4 years apart documented progressive decrease in the left hippocampal volume. Left anterior temporal lobectomy with amygdalohippocampectomy rendered the patient seizure free at 12 months' follow-up. The findings demonstrate that patients with uncontrolled temporal lobe seizures may develop progressive atrophy of the hippocampus, in the absence of status epilepticus. Ann Neurol 1999;45:526–529
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